Yu Yaqin, Tao Ran, Shi Jieping, Zhang Xiaojuan, Kou Changgui, Guo Yingjun, Zhang Xuan, Lin Xie, Liu Shuzheng, Ju Guizhi, Xu Qi, Shang Hong, Shen Yan, Wei Jun
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):351-4. doi: 10.1016/j.plefa.2005.07.003.
The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.
