Wei Jun, Hemmings Gwynneth P
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK.
Prostaglandins Leukot Essent Fatty Acids. 2005 Dec;73(6):441-5. doi: 10.1016/j.plefa.2005.08.003. Epub 2005 Sep 21.
The present study attempts to test the combined effect of the CLDN5 gene and those for the phospholipid metabolism pathway, including PTGS1, PTGS2, PLA2G4A and PLA2G4C. We detected five single nucleotide polymorphisms (SNPs) present in these genes among 131 British family trios of schizophrenic patients. The transmission disequilibrium test (TDT) showed that BanI-SNP located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia (chi(2) = 5.16, P = 0.023) although the others failed to show such allelic associations. The global P-value was 0.150 for 1000 permutations with the TDT analysis. The conditioning on genotype test, but not on allele test, revealed a strong association for the combination of the CLDN5 gene with the PLA2G4A gene (chi(2) = 10.17, df = 2, P = 0.006). The present results suggest that the PLA2G4A locus may be involved in schizophrenia and its combination with the CLDN5 gene may increase further the risk for the illness.
本研究试图检验CLDN5基因与磷脂代谢途径相关基因（包括PTGS1、PTGS2、PLA2G4A和PLA2G4C）的联合效应。我们在131个英国家庭的精神分裂症患者三联体中检测了这些基因中的五个单核苷酸多态性（SNP）。传递不平衡检验（TDT）表明，位于PLA2G4A基因5'侧翼区域的BanI-SNP与精神分裂症相关（χ² = 5.16，P = 0.023），尽管其他SNP未显示出这种等位基因关联。TDT分析进行1000次排列后的全局P值为0.150。基于基因型检验而非等位基因检验，揭示了CLDN5基因与PLA2G4A基因的组合存在强关联（χ² = 10.17，自由度 = 2，P = 0.006）。目前的结果表明，PLA2G4A基因座可能与精神分裂症有关，并且它与CLDN5基因的组合可能会进一步增加患该病的风险。
