Riera-Fortuny C, Real J T, Chaves F J, Morales-Suárez-Varela M, Martínez-Triguero M L, Morillas-Ariño C, Hernández-Mijares A
Hospital Universitario Dr. Peset, Valencia, Spain.
Int J Obes (Lond). 2005 Jan;29(1):78-84. doi: 10.1038/sj.ijo.0802829.
To analyse the relation between overweight, obesity and fat distribution with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene and its association with coronary heart disease (CHD).
Cross-sectional, case-control study.
A total of 185 cases (141 males) who had suffered at least one episode of CHD and 182 controls (127 males).
Body mass index, waist circumference, blood pressure, plasma total cholesterol, triglycerides, HDL cholesterol and fasting glucose were measured with standard methods, genotyping the I/D polymorphism of ACE gene.
Obesity and abdominal fat deposit are associated with CHD in women, but not independently. We have found an association between obesity and abdominal fat deposit with the ACE gene I/D polymorphism in subjects with CHD. Subjects with CHD and DD or ID genotypes have significantly higher prevalence of obesity and abdominal fat deposit and higher values of weight and waist circumference. In addition, the DD and ID genotypes increased crude OR of obesity. The DD and ID genotypes of the ACE gene I/D polymorphism and BMI are independently associated with CHD.
There is a relation between the type and grade of obesity with the genotypes of the ACE gene I/D polymorphism in subjects with CHD.
分析超重、肥胖及脂肪分布与血管紧张素转换酶（ACE）基因I/D多态性之间的关系及其与冠心病（CHD）的关联。
横断面病例对照研究。
共185例（141例男性）至少发生过一次冠心病的患者及182例对照者（127例男性）。
采用标准方法测量体重指数、腰围、血压、血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇和空腹血糖，对ACE基因的I/D多态性进行基因分型。
肥胖和腹部脂肪堆积与女性冠心病相关，但并非独立相关。我们发现冠心病患者中肥胖和腹部脂肪堆积与ACE基因I/D多态性之间存在关联。患有冠心病且基因型为DD或ID的受试者肥胖和腹部脂肪堆积的患病率显著更高，体重和腰围值也更高。此外，DD和ID基因型增加了肥胖的粗比值比。ACE基因I/D多态性的DD和ID基因型与体重指数独立地与冠心病相关。
冠心病患者中肥胖的类型和程度与ACE基因I/D多态性的基因型之间存在关联。
