Baldassarri L, Creti R, Arciola C R, Montanaro L, Venditti M, Di Rosa R
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
Clin Microbiol Infect. 2004 Nov;10(11):1006-8. doi: 10.1111/j.1469-0691.2004.00999.x.
Eleven isolates of Enterococcus faecalis causing endocarditis were screened for possible virulence factors with PCR and phenotypic assays. The gene coding for the enterococcal surface protein (esp) was detected in one isolate only, and haemolysin was produced by two isolates. Aggregation substance, biofilm formation and gelatinase were present in seven, nine and eight isolates, respectively. Predisposing factors, particularly hospitalisation and multiple antibiotic therapy, appeared to be more relevant to the development of enterococcal endocarditis following bloodstream infections than the pattern of virulence factors.
采用聚合酶链反应（PCR）和表型分析方法，对11株引起心内膜炎的粪肠球菌分离株进行了潜在毒力因子筛查。仅在1株分离株中检测到编码肠球菌表面蛋白（esp）的基因，2株分离株产生溶血素。分别有7株、9株和8株分离株存在聚集物质、生物膜形成和明胶酶。与毒力因子模式相比，易感因素，尤其是住院和多种抗生素治疗，似乎与血流感染后肠球菌心内膜炎的发生更为相关。
