Cooke Brian M, Lingelbach Klaus, Bannister Lawrence H, Tilley Leann
Department of Microbiology, Monash University, Victoria 3800, Australia.
Trends Parasitol. 2004 Dec;20(12):581-9. doi: 10.1016/j.pt.2004.09.008.
Plasmodium falciparum inhabits a niche within the most highly terminally differentiated cell in the human body--the mature red blood cell. Life inside this normally quiescent cell offers the parasite protection from the host's immune system, but provides little in the way of cellular infrastructure. To survive and replicate in the red blood cell, the parasite exports proteins that interact with and dramatically modify the properties of the host red blood cell. As part of this process, the parasite appears to establish a system within the red blood cell cytosol that allows the correct trafficking of parasite proteins to their final cellular destinations. In this review, we examine recent developments in our understanding of the pathways and components involved in the delivery of important parasite-encoded proteins to their final destination in the host red blood cell. These complex processes are not only fundamental to the survival of malaria parasites in vivo, but are also major determinants of the unique pathogenicity of this parasite.
恶性疟原虫寄生于人体中终末分化程度最高的细胞——成熟红细胞内。在这个通常处于静止状态的细胞内生存，为寄生虫提供了免受宿主免疫系统攻击的保护，但几乎没有提供细胞基础设施。为了在红细胞中生存和繁殖，寄生虫输出与宿主红细胞相互作用并显著改变其特性的蛋白质。作为这个过程的一部分，寄生虫似乎在红细胞胞质溶胶中建立了一个系统，允许寄生虫蛋白质正确运输到它们最终的细胞目的地。在这篇综述中，我们研究了在理解将重要的寄生虫编码蛋白质输送到宿主红细胞最终目的地所涉及的途径和成分方面的最新进展。这些复杂的过程不仅是疟原虫在体内生存的基础，也是这种寄生虫独特致病性的主要决定因素。
