Conklin Kenneth A
Department of Anesthesiology, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles 90095-1778, USA.
Integr Cancer Ther. 2004 Dec;3(4):294-300. doi: 10.1177/1534735404270335.
Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cell cycle checkpoint arrest, effects that may interfere with the ability of anticancer drugs to kill cancer cells. The aldehydes may also inhibit drug-induced apoptosis (programmed cell death) by inactivating death receptors and inhibiting caspase activity. These effects would also diminish the efficacy of the treatment. The use of anti-oxidants during chemotherapy may enhance therapy by reducing the generation of oxidative stress-induced aldehydes.
抗肿瘤药物在生物系统中会诱导氧化应激。在癌症化疗期间，氧化应激诱导的脂质过氧化会产生大量亲电醛类，这些醛类可攻击许多细胞靶点。氧化应激的这些产物会减缓癌细胞的细胞周期进程，并导致细胞周期检查点停滞，这些效应可能会干扰抗癌药物杀死癌细胞的能力。醛类还可能通过使死亡受体失活和抑制半胱天冬酶活性来抑制药物诱导的细胞凋亡（程序性细胞死亡）。这些效应也会降低治疗效果。化疗期间使用抗氧化剂可能通过减少氧化应激诱导的醛类的产生来增强治疗效果。
