Anderson Nicholas G, Regillo Carl
Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA.
Curr Opin Ophthalmol. 2004 Dec;15(6):503-7. doi: 10.1097/01.icu.0000143684.22362.46.
A review of the current literature regarding the ocular manifestations and management of graft versus host disease is presented.
A variety of systemic and topical anti-inflammatory or immunomodulatory agents, including prednisolone acetate, cyclosporine A, FK506, autologous serum, and retinoic acid show promise in controlling ocular graft versus host disease.
Graft versus host disease is a common manifestation of allogeneic stem cell transplantation. Ocular manifestations are found in a majority of patients and may be the presenting symptom. Ocular findings include keratoconjunctivitis sicca, pseudomembranous conjunctivitis, corneal ulceration and perforation, and microvascular retinopathy. Systemic and local therapy may be used to control ocular disease.
本文对目前有关移植物抗宿主病眼部表现及治疗的文献进行综述。
多种全身及局部抗炎或免疫调节药物，包括醋酸泼尼松龙、环孢素A、他克莫司、自体血清和视黄酸，在控制眼部移植物抗宿主病方面显示出前景。
移植物抗宿主病是异基因干细胞移植的常见表现。大多数患者会出现眼部表现，且可能是首发症状。眼部表现包括干眼症、假膜性结膜炎、角膜溃疡和穿孔以及微血管视网膜病变。可采用全身和局部治疗来控制眼部疾病。
