Department of Ophthalmology, Peking University Third Hospital, No.49 Garden North Road, Haidian, Beijing, 100191, China.
Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.
BMC Ophthalmol. 2022 Jan 10;22(1):18. doi: 10.1186/s12886-022-02251-y.
To determine the role tear lymphotoxin-α (LT-α) in chronic ocular graft-versus-host disease (oGVHD).
Twenty-two chronic oGVHD and 17 control tear samples were collected, and commercial test strips were used to detect LT-α concentrations. Concentration differences between patients with and without oGVHD were determined via Mann-Whitney U test. The correlation between LT-α levels and ophthalmic parameters was analyzed using Spearman's test.
The concentration of LT-α was significantly lower in oGVHD patients than in controls. LT-α levels were significantly correlated with OSDI, NIH eye score, T-BUT, and CFS among all participants. ROC analysis revealed that the area under the curve of LT-α was 0.847, and the cutoff value for chronic oGVHD diagnosis was 0.203 ng/mL.
Our study revealed the significant decrease of tear LT-α in oGVHD, and suggested LT-α as a promising marker for chronic oGVHD diagnosis.
确定泪液淋巴毒素-α（LT-α）在慢性眼移植物抗宿主病（oGVHD）中的作用。
收集 22 例慢性 oGVHD 和 17 例对照的泪液样本，并使用商业检测条检测 LT-α浓度。通过 Mann-Whitney U 检验确定 oGVHD 患者和无 oGVHD 患者之间的浓度差异。使用 Spearman 检验分析 LT-α 水平与眼科参数之间的相关性。
oGVHD 患者的 LT-α 浓度明显低于对照组。在所有参与者中，LT-α 水平与 OSDI、NIH 眼评分、T-BUT 和 CFS 均呈显著相关。ROC 分析显示，LT-α 的曲线下面积为 0.847，慢性 oGVHD 诊断的截断值为 0.203ng/mL。
本研究揭示了 oGVHD 患者泪液 LT-α 的显著降低，并提示 LT-α 可能成为诊断慢性 oGVHD 的有前途的标志物。
