组装线粒体外膜。
Assembling the mitochondrial outer membrane.
作者信息
Pfanner Nikolaus, Wiedemann Nils, Meisinger Chris, Lithgow Trevor
机构信息
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.
出版信息
Nat Struct Mol Biol. 2004 Nov;11(11):1044-8. doi: 10.1038/nsmb852.
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and assembly of outer-membrane proteins, revealing unexpected connections to mitochondrial evolution and morphology.
线粒体外膜的一般前体蛋白转位酶（TOM复合体）几乎能转运所有线粒体前体蛋白，但无法将外膜前体组装成功能复合体。最近发现的分选与组装机制（SAM复合体）对于外膜蛋白的整合与组装至关重要，揭示了与线粒体进化和形态的意外联系。
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