Wegrzyn Jacek
I Kliniki Psychiatrycznej IPiN w Warszawie.
Psychiatr Pol. 2004 Sep-Oct;38(5):833-45.
The paper presents a review of recent data on research and clinical significance of gating of the P50 component of the auditory evoked potentials (AEP). Information filters are a necessary element for the proper functioning of the brain. It appears as though they have an important role in the information-transfer mechanisms. Neurophysiologically, they appear hypothetically in the sensory gating of the P50 component of the AEP. Schizophrenic patients and their first degree relatives do not have proper sensory gating of the P50 AEP. This suggests that there is a common biological base for these disorders. Some clinical aspects of the schizophrenic psychoses can be linked to this disordered gating. There are also notes which show the contrary. Currently we do not know whether the improper sensory gating of the P50 AEP is a trait endophenotypically linked to schizophrenia, or only something that partially explains the pathophysiology of the illness--especially since the described phenomena may be evoked in healthy persons.
本文综述了近期关于听觉诱发电位（AEP）中P50成分门控的研究数据及其临床意义。信息过滤是大脑正常运作的必要要素。它们似乎在信息传递机制中发挥着重要作用。从神经生理学角度来看，它们可能假设性地出现在AEP的P50成分的感觉门控中。精神分裂症患者及其一级亲属的P50 AEP没有正常的感觉门控。这表明这些疾病存在共同的生物学基础。精神分裂症性精神病的一些临床方面可能与这种门控紊乱有关。也有一些记录显示情况相反。目前我们尚不清楚P50 AEP的感觉门控异常是一种与精神分裂症在表型上相关的特质，还是仅仅是部分解释该疾病病理生理学的因素——特别是因为所描述的现象也可能在健康人身上诱发。
