Poreba Rafał, Skoczyńska Anna, Derkacz Arkadiusz, Wojakowska Anna, Turczyn Barbara
Kliniki Chorób Wewnetrznych, Zawodowych i Nadciśnienia Tetniczego, Akademii Medycznej we Wrocławiu.
Med Pr. 2004;55(2):145-51.
Endothelial dysfunction is a pathology resulting from smoking and occupational exposure to lead. The aim of the study was to examine the influence of cigarette smoking on biochemical parameters of endothelial function in people occupationally exposed to lead.
The study covered 105 men, including 43 lead exposed copper-smelters (mean age 49.9 +/- 4.1) and 62 non-exposed men (mean age 47.3 +/- 9.3) formed the control group. In all subjects, peripheral blood lipid concentrations, biochemical parameters of endothelial function (nitric oxide, endothelin-1, sICAM-1, selectin-E) and inflammation parameters (interleukin-1beta, interleukin-6) were measured.
In the group of smokers, including both copper-smelters and control subjects, serum nitric oxide concentrations were lower than in non-smokers. In the serum of men occupationally exposed to lead, sICAM-1 concentrations were higher than in the control group. The lack of physiological correlation between serum concentration of nitric oxide and endothelin-1 resulted from interactions of tobacco smoking with lead exposure.
Workers occupationally exposed to lead should be informed about adverse effects of tobacco smoking in terms of the interaction between nicotine and lead, two combined toxic agents affecting the circulatory system.
内皮功能障碍是吸烟和职业性铅暴露导致的一种病理状态。本研究的目的是探讨吸烟对职业性铅暴露人群内皮功能生化参数的影响。
本研究涵盖105名男性，其中包括43名职业性铅暴露的铜冶炼工人（平均年龄49.9±4.1岁）和62名未暴露的男性（平均年龄47.3±9.3岁）作为对照组。检测所有受试者的外周血脂浓度、内皮功能生化参数（一氧化氮、内皮素-1、可溶性细胞间黏附分子-1、E-选择素）和炎症参数（白细胞介素-1β、白细胞介素-6）。
在吸烟者组中，包括铜冶炼工人和对照组受试者，血清一氧化氮浓度均低于非吸烟者。在职业性铅暴露男性的血清中，可溶性细胞间黏附分子-1浓度高于对照组。吸烟与铅暴露的相互作用导致血清一氧化氮浓度与内皮素-1之间缺乏生理相关性。
应告知职业性铅暴露工人吸烟在尼古丁与铅相互作用方面的不良影响，尼古丁和铅这两种联合毒物会影响循环系统。
