[Experimental study on treatment of minimal change nephropathy with niaozhuoqing].

OBJECTIVE

To study the therapeutic effect of niaozhuoqing on minimal change nephropathy (MCN) in rats.

METHODS

The MCN rat model was induced by intravenous injection of adriamycin. The effect of treatment on 24h urine protein, serum protein, lipid metabolism, malondialdehyde (MDA), superoxide dismutase (SOD) in serum, and renal histopathological changes were observed.

RESULTS

Niaozhuoqing could decrease the contents of proteinuria, blood lipid and MDA in serum, increase serum protein, SOD level and pathologically restore the glomeruli.

CONCLUSION

Niaozhuoqing has good effects on MCN, which probably related to decrease serum lipids level and reduce oxygen free radicals.