Wang Cai-Yun, Deng Hong-Zhu, Li Hui
Traditional Chinese Medicine Department, First Military Medical University, Guangzhou 510515, China.
Zhongguo Zhong Yao Za Zhi. 2005 Apr;30(8):614-7.
To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
Lespedeza Michx was effective on MCN.
研究鸡眼草对实验性大鼠微小病变肾病（MCN）模型的治疗作用。
通过尾静脉注射阿霉素复制大鼠MCN模型。通过检测24小时尿蛋白收集量、血清中丙二醛（MDA）、超氧化物歧化酶（SOD）、ATCO、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）来确定鸡眼草的治疗效果，并通过显微镜观察肾脏组织病理学变化。
鸡眼草可降低血清中尿蛋白、MDA、IL-8和TNF-α的含量，提高SOD水平，并改善肾小球的病理变化。
鸡眼草对MCN有效。
