Homeida A M, Al-Eknah M M
College of Veterinary Medicine and Animal Resources, King Faisal University, Saudi Arabia.
J Reprod Fertil. 1992 Jan;94(1):279-85. doi: 10.1530/jrf.0.0940279.
Early corpus luteum development in nonpregnant and pregnant goats was characterized by a steady increase in peripheral plasma concentrations of progesterone and a high release of prostacyclin (PGI-2) but low release of prostaglandin F-2 alpha (PGF-2 alpha). Jugular administration of oxytocin antagonist (OXA) (0.2 microgram/kg/day) on the day of oestrus and for 3 days thereafter to cyclic and mated goats, significantly (P less than 0.001) inhibited progesterone and prostaglandin secretion and reduced conception rate. Co-administration of PGI-2 (200 micrograms/day) with OXA resulted in a steady increase of progesterone and establishment of pregnancy, but co-administration of PGF-2 alpha (175 micrograms/day) with OXA had no effect. It is suggested that oxytocin is required for early development of the corpus luteum and such effects may be mediated via PGI-2 production.
未怀孕和怀孕山羊早期黄体发育的特征是外周血中孕酮浓度稳步升高，前列环素（PGI-2）释放量高，但前列腺素F-2α（PGF-2α）释放量低。在发情当天及此后3天，对发情周期正常和已交配的山羊颈静脉注射催产素拮抗剂（OXA）（0.2微克/千克/天），显著（P<0.001）抑制了孕酮和前列腺素的分泌，并降低了受孕率。PGI-2（200微克/天）与OXA联合使用可使孕酮稳步增加并成功怀孕，但PGF-2α（175微克/天）与OXA联合使用则无此效果。研究表明，催产素是黄体早期发育所必需的，这种作用可能是通过PGI-2的产生介导的。
