Cooke R G, Homeida A M
J Reprod Fertil. 1985 Sep;75(1):63-8. doi: 10.1530/jrf.0.0750063.
Active immunization against oxytocin significantly prolonged the oestrous cycle in 3 out of 4 goats; the mean (+/- s.e.m.) cycle length was 29.1 +/- 1.7 days (n = 12) compared to 19.4 +/- 0.6 days (n = 9) in control animals. During Days 10-21 of the cycle in the 3 responsive goats, peripheral plasma concentrations of progesterone and oxytocin were steady and those of 13,14-dihydro-15-keto-prostaglandin F-2 alpha were very low (50-100 pg X ml-1) with no marked pulsatile activity. The major effect of immunization would appear to be suppression of the synthesis of the uterine luteolysin PGF-2 alpha, thus confirming that endogenous oxytocin has a facilitatory role in luteolysis via prostaglandin production.
对4只山羊中的3只进行抗催产素主动免疫，显著延长了发情周期；平均（±标准误）周期长度为29.1±1.7天（n = 12），而对照动物为19.4±0.6天（n = 9）。在3只反应性山羊的周期第10 - 21天，外周血中孕酮和催产素浓度稳定，13,14 - 二氢 - 15 - 酮 - 前列腺素F - 2α浓度非常低（50 - 100 pg·ml⁻¹），且无明显的脉冲式活动。免疫的主要作用似乎是抑制子宫溶黄体素PGF - 2α的合成，从而证实内源性催产素通过前列腺素的产生在黄体溶解过程中起促进作用。
