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2019冠状病毒病大流行期间的炎症性肠病:影响、管理策略及经验教训

Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned.

作者信息

Gajendran Mahesh, Perisetti Abhilash, Aziz Muhammad, Raghavapuram Saikiran, Bansal Pardeep, Tharian Benjamin, Goyal Hemant

机构信息

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, TX (Mahesh Gajendran).

Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR (Abhilash Perisetti, Benjamin Tharian).

出版信息

Ann Gastroenterol. 2020 Nov-Dec;33(6):591-602. doi: 10.20524/aog.2020.0547. Epub 2020 Oct 12.

Abstract

The current outbreak of COVID-19 pandemic caused by SARS-CoV-2 has affected nearly 188 countries. Patients with severe COVID-19 are more commonly elderly and suffer from comorbidities such as hypertension, diabetes mellitus, coronary artery disease, chronic pulmonary disease, obesity, and cancer. Inflammatory bowel disease (IBD) affects as many as 6.8 million people globally, and a significant proportion of them are treated with immunosuppressants. Hence, there is an ongoing concern over the impact of COVID-19 on IBD patients and their susceptibility to it. So far, there are about 1439 IBD patients in the Surveillance Epidemiology of Coronavirus under Research Exclusion (SECURE-IBD) registry reported to be infected with SARS-CoV-2. There are many unique challenges and dilemmas that need to be taken into account when managing an IBD patient with COVID-19. The management of each patient should be individualized. The IBD societies and experts have strongly recommended that patients should not discontinue their IBD medications. If the patients have symptoms of COVID-19 or IBD flare-up, they are recommended to call their IBD physician first to discuss their medication. In addition, IBD patients are urged to practice social distancing strictly to minimize the chances of infection. As COVID-19 is rapidly evolving, our experience and understanding of its impact on the IBD population may potentially change in the near future.

摘要

由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引发的新型冠状病毒肺炎(COVID-19)疫情已影响了近 188 个国家。重症 COVID-19 患者多为老年人,且常伴有高血压、糖尿病、冠状动脉疾病、慢性肺病、肥胖症和癌症等合并症。炎症性肠病(IBD)在全球影响着多达 680 万人,其中很大一部分患者正在接受免疫抑制剂治疗。因此,人们一直担心 COVID-19 对 IBD 患者的影响以及他们对该病毒的易感性。截至目前,在“研究排除冠状病毒监测流行病学(SECURE-IBD)”登记处报告的约 1439 名 IBD 患者感染了 SARS-CoV-2。在管理 COVID-19 合并 IBD 的患者时,有许多独特的挑战和困境需要考虑。每位患者的管理都应个体化。IBD 协会和专家强烈建议患者不要停用 IBD 药物。如果患者出现 COVID-19 症状或 IBD 病情复发,建议他们首先致电 IBD 医生讨论用药问题。此外,敦促 IBD 患者严格保持社交距离,以尽量减少感染几率。由于 COVID-19 正在迅速演变,我们对其对 IBD 人群影响的经验和理解在不久的将来可能会发生变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5170/7599345/246b3c5ac97c/AnnGastroenterol-33-591-g001.jpg

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