Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin H L, Hayoz D
Laboratory of Hemodynamics and Cardiovascular Technology, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Cell Mol Life Sci. 2004 Oct;61(19-20):2614-23. doi: 10.1007/s00018-004-4225-6.
Cytoskeletal rearrangement occurs in a variety of cellular processes and involves a wide spectrum of proteins. Among these, the gelsolin superfamily proteins control actin organization by severing filaments, capping filament ends and nucleating actin assembly [1]. Gelsolin is the founding member of this family, which now contains at least another six members: villin, adseverin, capG, advillin, supervillin and flightless I. In addition to their respective role in actin filament remodeling, these proteins have some specific and apparently non-overlapping particular roles in several cellular processes, including cell motility, control of apoptosis and regulation of phagocytosis (summarized in table 1). Evidence suggests that proteins belonging to the gelsolin superfamily may be involved in other processes, including gene expression regulation. This review will focus on some of the known functions of the gelsolin superfamily proteins, thus providing a basis for reflection on other possible and as yet incompletely understood roles for these proteins.
细胞骨架重排在多种细胞过程中发生，涉及多种蛋白质。其中，凝溶胶蛋白超家族蛋白通过切断细丝、封闭细丝末端和成核肌动蛋白组装来控制肌动蛋白的组织[1]。凝溶胶蛋白是该家族的创始成员，现在至少还包含另外六个成员：绒毛蛋白、抗切蛋白、CapG、前绒毛蛋白、超级绒毛蛋白和无翅蛋白I。除了它们在肌动蛋白丝重塑中的各自作用外，这些蛋白质在包括细胞运动、细胞凋亡控制和吞噬作用调节在内的几个细胞过程中具有一些特定且明显不重叠的特殊作用（总结于表1）。有证据表明，属于凝溶胶蛋白超家族的蛋白质可能参与其他过程，包括基因表达调控。本综述将聚焦于凝溶胶蛋白超家族蛋白的一些已知功能，从而为思考这些蛋白质其他可能的、尚未完全理解的作用提供基础。
