Wang Xiong-Yi, Zhang Rui-Zhi, Wang Yi-Ke, Pan Sheng, Yun Si-Min, Li Jun-Jie, Xu You-Jia
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
J Orthop Translat. 2024 Oct 3;49:37-48. doi: 10.1016/j.jot.2024.08.015. eCollection 2024 Nov.
Osteoporosis is a chronic metabolic disease that increases bone fragility and, leads to severe osteoporotic fractures. In recent years, the use of high-throughput omics to explore physiological and pathological biomarkers related to bone metabolism has gained popularity. In this review, we first briefly review the technical approaches of proteomics. Additionally, we summarize the relevant literature in the last decade to provide a comprehensive overview of advances in human proteomics related to osteoporosis. We describe the specific roles of various proteins related to human bone metabolism, highlighting their potential as biomarkers for risk assessment, early diagnosis and disease course monitoring in osteoporosis. Finally, we outline the main challenges currently faced by human proteomics in the field of osteoporosis and offer suggestions to address these challenges, to inspire the search for novel osteoporosis biomarkers and a foundation for their clinical translation. In conclusion, proteomics is a powerful tool for discovering osteoporosis-related biomarkers, which can not only provide risk assessment, early diagnosis and disease course monitoring, but also reveal the underlying mechanisms of disease and provide key information for personalized treatment.
This review provides an insightful summary of recent human-based studies on osteoporosis-associated proteomics, which can aid the search for novel osteoporosis biomarkers based on human proteomics and the clinical translation of research results.
骨质疏松症是一种慢性代谢性疾病，会增加骨骼脆性并导致严重的骨质疏松性骨折。近年来，利用高通量组学技术探索与骨代谢相关的生理和病理生物标志物受到广泛关注。在本综述中，我们首先简要回顾蛋白质组学的技术方法。此外，我们总结了过去十年的相关文献，以全面概述与骨质疏松症相关的人类蛋白质组学进展。我们描述了与人类骨代谢相关的各种蛋白质的具体作用，强调了它们作为骨质疏松症风险评估、早期诊断和病程监测生物标志物的潜力。最后，我们概述了目前人类蛋白质组学在骨质疏松症领域面临的主要挑战，并提出应对这些挑战的建议，以激发对新型骨质疏松症生物标志物的探索及其临床转化的基础。总之，蛋白质组学是发现骨质疏松症相关生物标志物的有力工具，不仅可以提供风险评估、早期诊断和病程监测，还可以揭示疾病的潜在机制并为个性化治疗提供关键信息。
本综述对近期基于人类的骨质疏松症相关蛋白质组学研究进行了有见地的总结，有助于基于人类蛋白质组学寻找新型骨质疏松症生物标志物以及研究结果的临床转化。
