Aratikatla Adarsh, Viswanathan Vibhu Krishnan, Ghandour Samir, Jain Vijay Kumar, Gupta Ashim
Medical School, The Royal College of Surgeons in Ireland, Dublin, IRL.
Department of Orthopedics, Dr Rela Institute and Medical Center, Chennai, IND.
Cureus. 2024 Nov 5;16(11):e73040. doi: 10.7759/cureus.73040. eCollection 2024 Nov.
Gold-induced cytokine (GOLDIC) is a novel orthobiologic approach utilizing gold particles to produce a serum rich in immunoregulating cytokines and growth factors, which is being explored for its potential in tissue regeneration and treating musculoskeletal issues like knee osteoarthritis (OA). This study aims to review its mechanism of action along with the outcomes of , preclinical, and clinical studies, with a secondary focus on documenting clinical trials related to its use in OA of the knee. A systematic search was conducted in four databases (Embase, Scopus, PubMed, Web of Science) for studies on GOLDIC therapy for knee OA, using specific keywords related to knee anatomy and OA. studies demonstrated that gold-containing compounds reduce nitric oxide production in chondrocytes, mitigating catabolic processes. Pre-clinical trials in horses with lameness showed significant symptom improvement. Clinical studies reported substantial improvements in pain, function, and joint homeostasis, with reduced synovial effusion and cytokine modulation following GOLDIC therapy. GOLDIC therapy, in addition to orthopedic indications such as for the management of OA of the knee, has also been investigated in non-orthopedic settings with early promising results. However, more research is needed to fully understand its mechanism of action and establish its clinical utility.
金诱导细胞因子（GOLDIC）是一种新型的顺势疗法，利用金颗粒产生富含免疫调节细胞因子和生长因子的血清，目前正在探索其在组织再生和治疗膝关节骨关节炎（OA）等肌肉骨骼问题方面的潜力。本研究旨在综述其作用机制以及临床前和临床研究的结果，其次重点记录与膝关节OA相关的临床试验。在四个数据库（Embase、Scopus、PubMed、Web of Science）中进行了系统检索，以查找关于GOLDIC治疗膝关节OA的研究，使用了与膝关节解剖结构和OA相关的特定关键词。研究表明，含金化合物可减少软骨细胞中一氧化氮的产生，减轻分解代谢过程。对跛行马匹进行的临床前试验显示症状有显著改善。临床研究报告称，GOLDIC治疗后疼痛、功能和关节内环境稳定有显著改善，滑膜积液减少，细胞因子得到调节。GOLDIC疗法除了用于治疗膝关节OA等骨科适应症外，还在非骨科环境中进行了研究，早期结果令人鼓舞。然而，需要更多的研究来充分了解其作用机制并确定其临床效用。
