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[肺栓塞中的急性肺心病。一个重要的预后因素及治疗策略选择的关键参数]

[Acute cor pulmonale in pulmonary embolism. An important prognostic factor and a critical parameter for the choice of a therapeutic strategy].

作者信息

Konstantinides S, Hasenfuss G

机构信息

Abteilung Kardiologie und Pneumologie, Klinikum der Georg-August-Universität Göttingen.

出版信息

Internist (Berl). 2004 Oct;45(10):1155-62. doi: 10.1007/s00108-004-1267-7.

DOI:10.1007/s00108-004-1267-7
PMID:15526175
Abstract

Venous thromboembolism remains one of the most frequent and threatening acute cardiovascular syndromes. Its incidence has remained constant over the last several years, both in Europe and the United States, accounting for approximately 1.5 cases per 1000 inhabitants per year. Every year about 100 cases of venous thromboembolism per 100,000 inhabitants are admitted to the hospital, and 10% of these patients die during the hospital stay. Particularly alarming is the fact that in 50-70% of all patients who die from an acute pulmonary embolism the diagnosis is only made after death. These facts emphasize not only the relevance of the problem of "acute pulmonary embolism," but also the need for optimization of current diagnostic and therapeutic strategies. Rapid identification of acute cor pulmonale with echocardiography and cardiac biomarkers has recently proven to be especially helpful in this regard.

摘要

静脉血栓栓塞仍然是最常见且危险的急性心血管综合征之一。在过去几年中,其发病率在欧洲和美国一直保持稳定,每年每1000名居民中约有1.5例发病。每年每10万居民中约有100例静脉血栓栓塞患者住院,其中10%的患者在住院期间死亡。特别令人担忧的是,在所有死于急性肺栓塞的患者中,有50%-70%是在死后才做出诊断。这些事实不仅强调了“急性肺栓塞”问题的重要性,也凸显了优化当前诊断和治疗策略的必要性。最近已证明,通过超声心动图和心脏生物标志物快速识别急性肺心病在这方面特别有帮助。

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Right ventricular enlargement on chest computed tomography: prognostic role in acute pulmonary embolism.胸部计算机断层扫描显示的右心室扩大:在急性肺栓塞中的预后作用
Circulation. 2004 May 25;109(20):2401-4. doi: 10.1161/01.CIR.0000129302.90476.BC. Epub 2004 May 17.
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Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism.脑钠肽可预测急性肺栓塞患者的右心衰竭。
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Cardiac biomarkers for risk stratification of patients with acute pulmonary embolism.
用于急性肺栓塞患者危险分层的心脏生物标志物
Circulation. 2003 Nov 4;108(18):2191-4. doi: 10.1161/01.CIR.0000100687.99687.CE.
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N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism.急性肺栓塞患者的N末端前脑钠肽
Eur Respir J. 2003 Oct;22(4):649-53. doi: 10.1183/09031936.03.00023303.
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Low pro-brain natriuretic peptide levels predict benign clinical outcome in acute pulmonary embolism.
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Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism.肝素联合阿替普酶与单用肝素治疗亚大面积肺栓塞患者的比较。
N Engl J Med. 2002 Oct 10;347(15):1143-50. doi: 10.1056/NEJMoa021274.
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Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism.心肌肌钙蛋白I和T在急性肺栓塞患者风险分层中的重要性。
Circulation. 2002 Sep 3;106(10):1263-8. doi: 10.1161/01.cir.0000028422.51668.a2.
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Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology.心血管危险因素与静脉血栓栓塞症发病率:血栓栓塞病因的纵向研究
Arch Intern Med. 2002 May 27;162(10):1182-9. doi: 10.1001/archinte.162.10.1182.
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Echocardiography in the management of pulmonary embolism.超声心动图在肺栓塞管理中的应用
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