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肺栓塞的分诊。

Triaging in pulmonary embolism.

机构信息

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

出版信息

Semin Respir Crit Care Med. 2012 Apr;33(2):156-62. doi: 10.1055/s-0032-1311794. Epub 2012 May 30.

Abstract

Risk stratification of patients with pulmonary embolism represents an important step and may help to guide initial therapeutic management. Pulmonary embolism can be stratified into several groups, with different risk of early death or complications based on the presence of several risk factors. High-risk pulmonary embolism is defined by shock or peripheral signs of hypoperfusion. It is a life-threatening emergency with high short-term mortality (>25%) requiring specific therapeutic strategy with inotropic agents and fibrinolysis. In normotensive patients with pulmonary embolism, the presence of right ventricular dysfunction assessed by echocardiography or myocardial injury based on elevated levels of biomarkers, is associated with an intermediate risk of early death. These patients require close monitoring, and the role of thrombolytic treatment is currently assessed in a large trial. Lastly, patients with normotensive pulmonary embolism and without right ventricular dysfunction or myocardial injury have a low risk of death and complications. These patients may be candidates for home treatment. Several scores combining these risk factors have been described.

摘要

肺栓塞患者的风险分层是一个重要步骤,可能有助于指导初始治疗管理。肺栓塞可以分为几类,根据存在的几种危险因素,早期死亡或并发症的风险不同。高危肺栓塞定义为休克或外周低灌注的体征。这是一种危及生命的紧急情况,短期死亡率很高(>25%),需要采用特定的治疗策略,包括正性肌力药物和纤溶治疗。在超声心动图评估右心室功能障碍或基于生物标志物升高的心肌损伤的血压正常的肺栓塞患者中,存在中危的早期死亡风险。这些患者需要密切监测,溶栓治疗的作用目前正在一项大型试验中评估。最后,血压正常的肺栓塞且无右心室功能障碍或心肌损伤的患者,死亡和并发症的风险较低。这些患者可能是家庭治疗的候选者。已经描述了几种结合这些危险因素的评分。

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