Howard Lauren L, Kearns Karen S, Clippinger Tracy L, Larsen R Scott, Morris Patrick J
Zoological Society of San Diego, San Diego Zoo, P.O. Box 120551, San Diego, California 92112, USA.
J Zoo Wildl Med. 2004 Sep;35(3):312-9. doi: 10.1638/03-090.
Twelve adult rhebok (Pelea capreolus) were immobilized using a combination of 0.4 mg/kg xylazine and either 0.01 mg/kg of carfentanil (n = 6) or 0.01 mg/kg etorphine (n = 6), delivered i.m. using a remote injection system. Induction and recovery times, heart rate, respiratory rate, rectal temperature, oxygen saturation, end-tidal CO2 (ETCO2), anesthetic depth, indirect blood pressure, and arterial blood gases were recorded. Rhebok were not intubated but nasal oxygen was administered. Forty minutes after induction, anesthesia was antagonized with naltrexone and yohimbine. Mean initial heart rate was significantly higher in the carfentanil group than in the etorphine group. Mean initial oxygen saturation was consistent with hypoxia in both the carfentanil group and the etorphine group. In both groups, arterial pH decreased and partial pressure of carbon dioxide increased during the first 15 min of anesthesia, and values were similar in both groups. These findings were consistent with respiratory acidosis and decreased ventilation. Values for respiratory rate, temperature, oxygen saturation, ETCO2, and blood pressure were similar for both groups at all time periods. During the first 5 min of anesthesia, rhebok in the carfentanil group were more responsive to stimuli than rhebok in the etorphine group. After administration of antagonists, time to first arousal was significantly shorter in the etorphine group than in the carfentanil group. Although cardiopulmonary values were similar for the two groups, rhebok in the carfentanil group were at a comparatively lighter plane of anesthesia, and some individuals in this group required additional manual and chemical restraint for medical procedures to be performed. In conclusion, for captive adult rhebok, 0.01 mg/kg of etorphine and 0.4 mg/kg of xylazine are recommended over 0.01 mg/kg carfentanil and 0.4 mg/kg xylazine because of qualitatively better anesthetic episodes and shorter recovery times.
使用0.4mg/kg甲苯噻嗪与0.01mg/kg卡芬太尼(n = 6)或0.01mg/kg埃托啡(n = 6)的组合,通过远程注射系统经肌肉注射,使12只成年南非山羚(Pelea capreolus)麻醉。记录诱导和恢复时间、心率、呼吸频率、直肠温度、血氧饱和度、呼气末二氧化碳(ETCO2)、麻醉深度、间接血压和动脉血气。南非山羚未进行插管,但给予了鼻内氧气。诱导后40分钟,用纳曲酮和育亨宾拮抗麻醉。卡芬太尼组的平均初始心率显著高于埃托啡组。卡芬太尼组和埃托啡组的平均初始血氧饱和度均与缺氧一致。两组在麻醉的前15分钟内动脉pH值均下降,二氧化碳分压均升高,且两组数值相似。这些发现与呼吸性酸中毒和通气减少一致。两组在所有时间段的呼吸频率、体温、血氧饱和度、ETCO2和血压值均相似。在麻醉的前5分钟内,卡芬太尼组的南非山羚对刺激的反应比埃托啡组的更敏感。给予拮抗剂后,埃托啡组的首次苏醒时间显著短于卡芬太尼组。尽管两组的心肺值相似,但卡芬太尼组的南非山羚处于相对较浅的麻醉平面,该组中的一些个体在进行医疗程序时需要额外的手动和化学约束。总之,对于圈养的成年南非山羚,推荐使用0.01mg/kg埃托啡和0.4mg/kg甲苯噻嗪,而不是0.01mg/kg卡芬太尼和0.4mg/kg甲苯噻嗪,因为其麻醉效果在质量上更好且恢复时间更短。