Re Michela, Blanco-Murcia Francisco J, San Miguel José Maria, Gómez de Segura Ignacio A
Department of Animal Medicine and Surgery, Veterinary Faculty, University Complutense, Avda, Puerta de Hierro s/n. 28040, Madrid, Spain (Re, Blanco-Murcia, Gómez de Segura); Pfizer Animal Health, Alcobendas, Spain (San Miguel).
Can J Vet Res. 2013 Oct;77(4):288-92.
The aim of this study was to determine the efficacy of a concentrated combination of tiletamine-zolazepam [TZ, 0.53 mg/kg body weight (BW)], ketamine (Ket, 0.53 mg/kg BW), and detomidine (Det, 0.04 mg/kg BW) in the immobilization of free-range cattle for clinical procedures. The combination was administered intramuscularly to 53 animals. Anesthesia was reversed with the α2-adrenoceptor antagonist atipamezole. Locoregional anesthesia was provided with lidocaine when required. The TZKD combination induced suitable immobilization for minor surgical procedures or medical treatments. Anesthetic onset was rapid, taking a mean of 6.1 min [standard deviation (SD) 2.8 min]. The duration of anesthesia depended on the time of administration of the antagonist; the animals recovered in the standing position in 12.9 ± 8.9 min after the administration of atipamezole. The quality of anesthesia and analgesia were satisfactory. In conclusion, this TZKD combination can be used for both immobilization and minor surgical procedures in free-range cattle.
本研究的目的是确定替来他明-唑拉西泮[TZ，0.53毫克/千克体重（BW）]、氯胺酮（Ket，0.53毫克/千克BW）和地托咪定（Det，0.04毫克/千克BW）的浓缩组合在固定散养牛以便进行临床操作方面的疗效。该组合通过肌肉注射给予53只动物。使用α2-肾上腺素能受体拮抗剂阿替美唑逆转麻醉。必要时用利多卡因进行局部麻醉。TZKD组合可为小型外科手术或医疗提供合适的固定效果。麻醉起效迅速，平均用时6.1分钟[标准差（SD）2.8分钟]。麻醉持续时间取决于拮抗剂的给药时间；给予阿替美唑后，动物在12.9±8.9分钟内站立恢复。麻醉和镇痛质量令人满意。总之，这种TZKD组合可用于散养牛的固定和小型外科手术。
