Lian Marianne, Evans Alina L, Bertelsen Mads F, Fahlman Åsa, Haga Henning A, Ericsson Göran, Arnemo Jon M
Acta Vet Scand. 2014 Aug 15;56(1):51. doi: 10.1186/s13028-014-0051-5.
The effect of intranasal oxygen and/or early reversal of xylazine with atipamezole on arterial oxygenation in free-ranging moose (Alces alces) immobilized with etorphine-acepromazine-xylazine with a cross-sectional clinical study on 33 adult moose was evaluated.
Before treatment the mean±SD (range) partial pressure of arterial oxygen (PaO2) was 62±17 (26-99) mmHg. Twenty-six animals had a PaO2<80 mmHg. Ten had a PaO2 of 40-60 mmHg and three animals had a PaO2<40 mmHg. Intranasal oxygen and intravenous administration of atipamezole significantly increased the mean PaO2, as did the combination of the two. In contrast, atipamezole administered intramuscularly at the evaluated dose had no significant effect on arterial oxygenation.
This study shows that intranasal oxygen effectively improved arterial oxygenation in immobilized moose, and that early intravenous reversal of the sedative component, in this case xylazine, in an opioid-based immobilization drug-protocol significantly improves arterial oxygenation.
通过对33头成年驼鹿进行横断面临床研究，评估了经鼻给氧和/或用阿替美唑早期逆转赛拉嗪对用埃托啡-乙酰丙嗪-赛拉嗪固定的自由放养驼鹿（驼鹿属）动脉氧合的影响。
治疗前，动脉血氧分压（PaO2）的平均值±标准差（范围）为62±17（26 - 99）mmHg。26只动物的PaO2<80 mmHg。10只动物的PaO2为40 - 60 mmHg，3只动物的PaO2<40 mmHg。经鼻给氧和静脉注射阿替美唑均显著提高了平均PaO2，两者联合使用效果相同。相比之下，以评估剂量肌肉注射阿替美唑对动脉氧合无显著影响。
本研究表明，经鼻给氧可有效改善固定驼鹿的动脉氧合，并且在基于阿片类药物的固定方案中，早期静脉逆转镇静成分（在本病例中为赛拉嗪）可显著改善动脉氧合。
