在一项比较促性腺激素释放激素激动剂与拮抗剂方案用于卵巢过度刺激的随机对照试验中，抑制素B血清水平与卵泡反应参数的相关性
Association of inhibin B serum levels with parameters of follicular response in a randomized controlled trial comparing gnRH agonist versus antagonist protocols for ovarian hyperstimulation.
作者信息
Sonntag Barbara, Kiesel Ludwig, Nieschlag Eberhard, Behre Hermann M
机构信息
Department of Obstetrics and Gynecology of the University, Albert-Schweitzer-Str. 33, 48149 Münster, Germany.
出版信息
J Assist Reprod Genet. 2004 Jul;21(7):249-55. doi: 10.1023/b:jarg.0000042010.86102.03.
PURPOSE
To study the association of inhibin B with ovarian response to FSH stimulation, applying either GnRH agonist or antagonist.
METHODS
In a prospective randomized controlled trial, 46 patients undergoing COH received either triptorelin (group I, n = 15) or ganirelix (group II, n = 31). Parameters of follicular response and inhibin B serum levels were assessed.
RESULTS
Inhibin B before FSH stimulation was significantly lower in group I than group II. The FSH stimulation phase was significantly longer in group I than group II, and the total FSH dose was significantly higher with a comparable number of retrieved oocytes. Day 1 inhibin B in group I, but not group II, was significantly correlated with the number of large ovarian follicles and retrieved oocytes. In group II, but not group I, inhibin B on day 1 was inversely correlated with the daily and total FSH dose as well as FSH stimulation duration.
CONCLUSIONS
The association of inhibin B serum levels with parameters of follicular response in COH is different in patients assigned to GnRH agonist vs. antagonist treatment protocols.
目的
应用促性腺激素释放激素（GnRH）激动剂或拮抗剂，研究抑制素B与卵巢对促卵泡激素（FSH）刺激反应的相关性。
方法
在一项前瞻性随机对照试验中，46例接受控制性卵巢刺激（COH）的患者分别接受曲普瑞林治疗（I组，n = 15）或加尼瑞克治疗（II组，n = 31）。评估卵泡反应参数和抑制素B血清水平。
结果
FSH刺激前，I组的抑制素B显著低于II组。I组的FSH刺激期显著长于II组，在获卵数相当的情况下，I组的FSH总剂量显著更高。I组第1天的抑制素B与大卵泡数和获卵数显著相关，而II组则不然。在II组而非I组中，第1天的抑制素B与每日和总FSH剂量以及FSH刺激持续时间呈负相关。
结论
在接受GnRH激动剂与拮抗剂治疗方案的患者中，COH时抑制素B血清水平与卵泡反应参数的相关性有所不同。
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