• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response.血清促卵泡激素升高及年龄对因卵巢反应不良导致体外受精治疗取消风险的实际影响。
J Assist Reprod Genet. 2004 Jul;21(7):257-62. doi: 10.1023/b:jarg.0000042011.67696.85.
2
Previous cycle cancellation due to poor follicular development as a predictor of ovarian response in cycles stimulated with gonadotrophin-releasing hormone agonist-gonadotrophin treatment.既往因卵泡发育不良导致周期取消作为促性腺激素释放激素激动剂 - 促性腺激素治疗刺激周期中卵巢反应的预测指标。
Hum Reprod. 2005 Mar;20(3):622-8. doi: 10.1093/humrep/deh674. Epub 2004 Dec 17.
3
Age and basal follicle stimulating hormone as predictors of in vitro fertilisation outcome.年龄和基础促卵泡激素作为体外受精结局的预测指标。
Br J Obstet Gynaecol. 1998 Jan;105(1):107-12. doi: 10.1111/j.1471-0528.1998.tb09360.x.
4
Ovarian reserve test with human menopausal gonadotropin as a predictor of in vitro fertilization outcome.以人绝经期促性腺激素进行卵巢储备功能检测作为体外受精结局的预测指标
J Assist Reprod Genet. 2000 Jan;17(1):13-9. doi: 10.1023/a:1009441812247.
5
Evaluation of the utility of multiple endocrine and ultrasound measures of ovarian reserve in the prediction of cycle cancellation in a high-risk IVF population.评估多种内分泌及超声测量卵巢储备功能指标在预测高危体外受精人群周期取消中的效用。
Hum Reprod. 2007 Mar;22(3):778-85. doi: 10.1093/humrep/del435. Epub 2006 Nov 17.
6
Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome.第3天血清抑制素B、卵泡刺激素以及年龄作为辅助生殖治疗结局的预测指标。
Hum Reprod. 2000 Nov;15(11):2341-6. doi: 10.1093/humrep/15.11.2341.
7
Follicle-stimulating hormone levels on cycle day 3 to predict ovarian response in women undergoing controlled ovarian hyperstimulation for in vitro fertilization using a flare-up protocol.在采用激发方案进行体外受精的控制性卵巢过度刺激的女性中，利用月经周期第3天的促卵泡生成素水平预测卵巢反应。
Fertil Steril. 1997 Sep;68(3):483-7. doi: 10.1016/s0015-0282(97)00246-x.
8
A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF: a multicenter randomized non-inferiority trial.一项针对卵巢储备功能低下的女性在体外受精时采用温和卵巢刺激策略的多中心随机非劣效性试验。
Hum Reprod. 2017 Jan;32(1):112-118. doi: 10.1093/humrep/dew282. Epub 2016 Nov 11.
9
High live birth rate in the subsequent IVF cycle after first-cycle poor response among women with mean age 35 and normal FSH.在平均年龄为 35 岁且 FSH 正常的患者中，首次周期反应不良后，后续 IVF 周期的活产率较高。
Reprod Biomed Online. 2013 Oct;27(4):362-6. doi: 10.1016/j.rbmo.2013.07.004. Epub 2013 Jul 18.
10
Antral follicle count and FSH concentration after clomiphene citrate challenge test in the prediction of ovarian response during IVF treatment.克罗米芬柠檬酸盐激发试验后的窦卵泡计数和促卵泡生成素浓度在体外受精治疗期间卵巢反应预测中的应用
Hum Reprod. 2005 Jun;20(6):1647-54. doi: 10.1093/humrep/deh833. Epub 2005 Feb 25.

引用本文的文献

1
Maximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a "better" month conveys limited retrieval benefits.基础促卵泡激素（FSH）的最高值比特定周期的基础FSH水平更能预测生殖结局：等待“更好的”月份所带来的取卵益处有限。
Reprod Biol Endocrinol. 2015 Aug 15;13:91. doi: 10.1186/s12958-015-0078-0.
2
Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization.通过体外受精，利用卵巢体积和窦卵泡计数预测低反应者和高反应者。
Reprod Biol Endocrinol. 2007 Mar 15;5:9. doi: 10.1186/1477-7827-5-9.

本文引用的文献

1
Biological versus chronological ageing of oocytes, distinguishable by raised FSH levels in relation to the success of IVF treatment.卵母细胞的生物学衰老与实际年龄衰老，可通过与体外受精治疗成功率相关的促卵泡激素水平升高来区分。
Hum Reprod. 2002 Aug;17(8):2003-8. doi: 10.1093/humrep/17.8.2003.
2
Increasing the gonadotrophin dose in the course of an in vitro fertilization cycle does not rectify an initial poor response.在体外受精周期中增加促性腺激素剂量并不能纠正最初的低反应。
Eur J Obstet Gynecol Reprod Biol. 2002 Jul 10;103(2):146-9. doi: 10.1016/s0301-2115(02)00036-2.
3
Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure?对卵巢过度刺激反应极差与卵巢早衰之间是否存在关联？
Hum Reprod. 2002 Apr;17(4):1106-11. doi: 10.1093/humrep/17.4.1106.
4
Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve.体外受精中卵巢反应不良的预测因素：一项比较卵巢储备基础标志物的前瞻性研究。
Fertil Steril. 2002 Feb;77(2):328-36. doi: 10.1016/s0015-0282(01)02983-1.
5
Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders.区分临床特征：预测良好反应者、反应不佳者和高反应者。
Fertil Steril. 2001 Dec;76(6):1185-90. doi: 10.1016/s0015-0282(01)02893-x.
6
Reproductive outcome in patients with diminished ovarian reserve.卵巢储备功能减退患者的生殖结局
Fertil Steril. 2001 Oct;76(4):666-9. doi: 10.1016/s0015-0282(01)02017-9.
7
Assessing fertility in women of advanced reproductive age.评估高龄育龄女性的生育能力。
Am J Obstet Gynecol. 2001 Sep;185(3):758-70. doi: 10.1067/mob.2001.114689.
8
Low-dose dexamethasone augments the ovarian response to exogenous gonadotrophins leading to a reduction in cycle cancellation rate in a standard IVF programme.低剂量地塞米松可增强卵巢对外源性促性腺激素的反应，从而降低标准体外受精方案中的周期取消率。
Hum Reprod. 2001 Sep;16(9):1861-5. doi: 10.1093/humrep/16.9.1861.
9
Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome.第3天血清抑制素B、卵泡刺激素以及年龄作为辅助生殖治疗结局的预测指标。
Hum Reprod. 2000 Nov;15(11):2341-6. doi: 10.1093/humrep/15.11.2341.
10
Dynamic assays of inhibin B and oestradiol following buserelin acetate administration as predictors of ovarian response in IVF.
Hum Reprod. 2000 Nov;15(11):2297-301. doi: 10.1093/humrep/15.11.2297.

血清促卵泡激素升高及年龄对因卵巢反应不良导致体外受精治疗取消风险的实际影响。

The practical implications of a raised serum FSH and age on the risk of IVF treatment cancellation due to a poor ovarian response.

作者信息

Akande Valentine A, Keay Stephen D, Hunt Linda P, Mathur Rajneesh S, Jenkins Julian M, Cahill David J

机构信息

Centre for Reproductive Medicine, Division of Obstetrics and Gynaecology, University of Bristol, St. Michael's Hospital, Bristol BS2 8EG, United Kingdom.

出版信息

J Assist Reprod Genet. 2004 Jul;21(7):257-62. doi: 10.1023/b:jarg.0000042011.67696.85.

DOI:10.1023/b:jarg.0000042011.67696.85
PMID:15526983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455186/
Abstract

PURPOSE

Chronological age, or biological age as indicated by elevated FSH levels, are related to ovarian reserve. This study addresses the likelihood of cancellation of IVF treatment due to a poor ovarian response utilising both basal serum FSH and woman's age.

METHODS

A prospective cohort of 536 infertile but ovulating women were studied in their first cycle of IVF treatment. Standardised methods of pituitary desensitisation and ovarian stimulation prior to IVF treatment were employed. Treatment cycles cancelled due to a poor ovarian response to gonadotrophins were studied. A series of logistic regression models were used to explore the probabilities of cancellation in relation to age and FSH.

RESULTS

Both age and basal serum FSH levels were independently associated with the risk of treatment cancellation. A low risk of treatment cancellation was observed in women under the age of 35 irrespective of serum FSH, however in older women the risk of treatment cancellation was most likely in women with a high FSH.

CONCLUSIONS

In combination both age and FSH may serve as a valuable indicator of poor ovarian response leading to treatment cancellation. However, among older women FSH has particular importance, while less so in younger women with regular menstrual cycles.

摘要

目的

按时间顺序计算的年龄，或由升高的促卵泡激素（FSH）水平所表明的生物学年龄，与卵巢储备有关。本研究探讨了利用基础血清FSH和女性年龄，因卵巢反应不良而取消体外受精（IVF）治疗的可能性。

方法

对536名不孕但排卵的女性进行前瞻性队列研究，观察她们的首次IVF治疗周期。采用IVF治疗前垂体脱敏和卵巢刺激的标准化方法。研究因对促性腺激素卵巢反应不良而取消的治疗周期。使用一系列逻辑回归模型来探讨与年龄和FSH相关的取消治疗的概率。

结果

年龄和基础血清FSH水平均与治疗取消风险独立相关。无论血清FSH如何，35岁以下女性治疗取消风险较低，然而在年龄较大的女性中，FSH水平高的女性治疗取消风险最高。

结论

年龄和FSH相结合可作为导致治疗取消的卵巢反应不良的重要指标。然而，在年龄较大的女性中FSH尤为重要，而在月经周期规律的年轻女性中重要性较低。