Gürgan T, Urman B, Yarali H, Duran H E
Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Fertil Steril. 1997 Sep;68(3):483-7. doi: 10.1016/s0015-0282(97)00246-x.
To determine whether cycle day 3 serum FSH levels predict poor ovarian response and cycle cancellation in women undergoing controlled ovarian hyperstimulation (COH) for IVF.
Prospective case series.
University hospital IVF program.
PATIENT(S): The study includes outcomes of 637 initial cycles of IVF.
INTERVENTION(S): Controlled ovarian hyperstimulation was undertaken with a short, flare-up GnRH agonist and hMG protocol. The relation of cycle day 3 FSH levels with various cycle characteristics and outcomes was determined.
MAIN OUTCOME MEASURE(S): The accuracy of cycle day 3 FSH levels in predicting poor ovarian response and cycle cancellation was evaluated. Receiver operating characteristic curves were constructed to determine the optimum cutoff value for the cycle day 3 serum FSH level that best predicted poor ovarian response and cycle cancellation.
RESULT(S): A cycle day 3 serum FSH level > or = 13 mIU/mL (conversion factor to SI unit, 1.00) was associated with a high likelihood of poor ovarian response and cycle cancellation. The sensitivity, specificity, and positive likelihood ratio of an FSH level of 13 mIU/mL in predicting cycle cancellation were 52%, 91%, and 6.04, respectively.
CONCLUSION(S): Cycle day 3 FSH screening appears to be a fairly accurate predictor of poor ovarian response and cycle cancellation in women undergoing COH using a short, flare-up GnRH agonist and hMG protocol.
确定在接受体外受精（IVF）控制性卵巢刺激（COH）的女性中，月经周期第3天血清促卵泡激素（FSH）水平是否可预测卵巢反应不良及周期取消。
前瞻性病例系列研究。
大学医院IVF项目。
该研究纳入了637个初始IVF周期的结果。
采用短效、激发型促性腺激素释放激素（GnRH）激动剂和人绝经期促性腺激素（hMG）方案进行控制性卵巢刺激。确定月经周期第3天FSH水平与各种周期特征和结果之间的关系。
评估月经周期第3天FSH水平预测卵巢反应不良和周期取消的准确性。构建受试者工作特征曲线以确定最能预测卵巢反应不良和周期取消的月经周期第3天血清FSH水平的最佳临界值。
月经周期第3天血清FSH水平≥13 mIU/mL（换算系数至国际单位制，1.00）与卵巢反应不良和周期取消的高可能性相关。FSH水平为13 mIU/mL预测周期取消的敏感性、特异性和阳性似然比分别为52%、91%和6.04。
对于采用短效、激发型GnRH激动剂和hMG方案进行COH的女性，月经周期第3天FSH筛查似乎是卵巢反应不良和周期取消的相当准确的预测指标。
