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Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype.具有西开普F11基因型的结核分枝杆菌的分子特征及全球传播
J Clin Microbiol. 2004 Feb;42(2):769-72. doi: 10.1128/JCM.42.2.769-772.2004.
2
Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain.孟加拉国结核分枝杆菌的基因分型分析及北京菌株的流行情况。
J Clin Microbiol. 2004 Feb;42(2):674-82. doi: 10.1128/JCM.42.2.674-682.2004.
3
Snapshot of moving and expanding clones of Mycobacterium tuberculosis and their global distribution assessed by spoligotyping in an international study.在一项国际研究中，通过间隔寡核苷酸分型技术评估结核分枝杆菌移动和扩展克隆的概况及其全球分布。
J Clin Microbiol. 2003 May;41(5):1963-70. doi: 10.1128/JCM.41.5.1963-1970.2003.
4
IS6110-mediated deletion polymorphism in the direct repeat region of clinical isolates of Mycobacterium tuberculosis.结核分枝杆菌临床分离株直接重复区域中IS6110介导的缺失多态性
J Bacteriol. 2003 May;185(9):2856-66. doi: 10.1128/JB.185.9.2856-2866.2003.
5
Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping data.结核分枝杆菌直接重复区域的微进化：对间隔寡核苷酸分型数据解释的影响
J Clin Microbiol. 2002 Dec;40(12):4457-65. doi: 10.1128/JCM.40.12.4457-4465.2002.
6
Identification of genes that are associated with DNA repeats in prokaryotes.原核生物中与DNA重复序列相关的基因的鉴定。
Mol Microbiol. 2002 Mar;43(6):1565-75. doi: 10.1046/j.1365-2958.2002.02839.x.
7
Discrimination of Mycobacterium tuberculosis complex bacteria using novel VNTR-PCR targets.利用新型VNTR-PCR靶点鉴别结核分枝杆菌复合群细菌
Microbiology (Reading). 2002 Feb;148(Pt 2):519-528. doi: 10.1099/00221287-148-2-519.
8
Epidemiological evidence of the spread of a Mycobacterium tuberculosis strain of the Beijing genotype on Gran Canaria Island.关于北京基因型结核分枝杆菌菌株在大加那利岛传播的流行病学证据。
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1165-70. doi: 10.1164/ajrccm.164.7.2101031.
9
Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units.基于分枝杆菌散布重复单位的用于结核分枝杆菌全球流行病学研究的自动化高通量基因分型
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10
Use of spoligotyping to study the evolution of the direct repeat locus by IS6110 transposition in Mycobacterium tuberculosis.利用间隔寡核苷酸分型技术研究结核分枝杆菌中IS6110转座导致的直接重复序列位点的进化。
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结核分枝杆菌同基因实验室菌株中直接可变重复序列缺失导致的寡核苷酸分型图谱变化

Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain.

作者信息

Aranaz Alicia, Romero Beatriz, Montero Natalia, Alvarez Julio, Bezos Javier, de Juan Lucía, Mateos Ana, Domínguez Lucas

机构信息

Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.

出版信息

J Clin Microbiol. 2004 Nov;42(11):5388-91. doi: 10.1128/JCM.42.11.5388-5391.2004.

DOI:10.1128/JCM.42.11.5388-5391.2004
PMID:15528751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC525166/
Abstract

Spoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases.

摘要

寡核苷酸分型是结核分枝杆菌复合群生物分子分型的主要工具。出于流行病学目的，只有当菌株的寡核苷酸分型模式相同时，才被认为是克隆性的。我们报告了由一个直接可变重复序列缺失导致的真正同基因菌株（一个临床分离株和一个实验室衍生的传代培养物）寡核苷酸分型谱的变化。如果没有它们之间关系的信息，这些菌株之间的联系就会被忽视。在解释寡核苷酸分型结果和设计数据库时，应考虑进化事件。