[进展期结直肠癌血行转移与浆膜层肿瘤浸润形态模式的相关性研究]

[Study on correlation of hematogenous metastasis in advanced colorectal cancer with the morphological mode of tumor invasion in the pm layer].

作者信息

Kanno M, Kurosaka Y, Kosaka T, Yamaguchi A, Yonemura Y, Miwa K, Miyazaki I

机构信息

Department of Surgery II, Kanazawa University School of Medicine, Japan.

出版信息

Nihon Geka Gakkai Zasshi. 1992 Feb;93(2):139-43.

PMID:1552885

Abstract

We studied the influence of the morphological mode of tumor invasion in muscularis propria (pm) layer, in 177 patients who received resection for colorectal carcinoma that invaded beyond the pm layer. Tapering Index (TI = A/B) defined from the ratio between the length of tumor invasion on upper pm layer (A) and that on lower pm layer (B), TI value was significantly lower in cases with hematogenous metastasis than that in cases without hematogenous metastasis. Cases in which TI values were under 1.3 in colon cancer and 1.9 in rectal cancer had higher possibility of synchronous or metachronous hematogenous metastasis and poorer prognosis. Therefore, we suspected that TI value would be an important factor in prediction of hematogenous metastasis.

摘要

我们研究了177例接受超过固有肌层（pm）侵犯的结直肠癌切除术患者中肿瘤在固有肌层侵犯的形态学模式的影响。通过肿瘤在上部固有肌层的侵犯长度（A）与下部固有肌层的侵犯长度（B）之比定义的渐细指数（TI = A/B），血行转移患者的TI值显著低于无血行转移患者。结肠癌TI值低于1.3且直肠癌TI值低于1.9的病例发生同时性或异时性血行转移的可能性更高，预后更差。因此，我们怀疑TI值将是预测血行转移的一个重要因素。