Saito Y, Ouchi A, Goto S, Nukada Y, Mizoi T, Matsuno S, Otani H
First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Nihon Geka Gakkai Zasshi. 1992 Feb;93(2):133-8.
We investigated the correlation between venous invasion and hematogenous metastasis. In thirteen patients with colorectal carcinoma, depth of invasion (ss.s or a1.a2) was the same. Four cases had hepatic metastasis at operation (group A), 3 cases were identified with hematogenous recurrence after operation (group B), and 6 cases were disease free over 10 years after operation (group C). Specimens were all step-sectioned and serial sections were stained both with HE and EM. Results were as follows. 1. Venous invasion was found in all cases and average rates of venous invasion (ARVI) of groups A and B were higher than that of group C (A; 7.8%, B; 6.3%, C; 2.1%, p less than 0.05). 2. In ss.s layer, ARVI of group A and B were higher than that of group C (A; 6.1%, B; 6.2%, C; 1.5%, p less than 0.05). 3. Rates of venous invasion to larger veins (diameter greater than 200 microns) were higher in group A than in others (A; 53.5%, B; 25.6%, C; 7.9%, p less than 0.05), and those to the middle-sized veins (diameter; 50-200 microns) were higher in group B than in others. These facts suggest that cancer invasion to the veins located in ss.s (a1.a2) layer or ranged in diameter over 200 microns relates to hematogenous metastasis.
我们研究了静脉侵犯与血行转移之间的相关性。在13例结肠癌患者中，浸润深度（ss.s或a1.a2）相同。4例患者在手术时有肝转移（A组），3例患者术后出现血行复发（B组），6例患者术后10年无疾病复发（C组）。所有标本均进行连续切片，系列切片分别用苏木精-伊红（HE）染色和电子显微镜（EM）染色。结果如下：1. 所有病例均发现有静脉侵犯，A组和B组的平均静脉侵犯率（ARVI）高于C组（A组：7.8%，B组：6.3%，C组：2.1%，p<0.05）。2. 在ss.s层，A组和B组的ARVI高于C组（A组：6.1%，B组：6.2%，C组：1.5%，p<0.05）。3. A组侵犯较大静脉（直径大于200微米）的静脉侵犯率高于其他组（A组：53.5%，B组：25.6%，C组：7.9%，p<0.05），B组侵犯中等大小静脉（直径50-200微米）的静脉侵犯率高于其他组。这些事实表明，癌症侵犯位于ss.s（a1.a2）层或直径超过200微米的静脉与血行转移有关。
