Blaj S, Jurcuţ C, Stanciu S, Sună Carmen, Ciobică L, Mureşan M, Rusu C
Internal Medicine I Department, Central Military Hospital, Bucharest, Romania.
Rom J Intern Med. 2004;42(1):111-8.
Higher values of pulse pressure (PP)--the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP)--are associated with an increased cardiovascular risk; SBP and DBP values are correlated with serum levels of gamma-glutamyl transferase (GGT), both in drinkers and non-drinkers subjects. Moreover, some studies showed that high levels of serum GGT might be related with an increased cardiovascular risk. However, few studies analyzed the relationship between GGT and PP. In 72 subjects (18 male; 54 women), middle-aged (mean age: 36.63 yrs; limits: 24-54 yrs), apparently healthy, we performed the measurements of: weight, height (from which we calculated the body mass index [BMI]), SBP, DBP, PP, standard biochemical workup, including GGT (UI/l).
PP values are correlated with SBP (r=0.74, p<0.001), but not with DBP (r=0.15, p=NS) values. GGT is significantly correlated with SBP (r=0.28, p=0.01), DBP (r=0.29, p=0.01), and BMI (r=0.41, p<0.001). Mean values of PP are significantly higher in those with a GGT>20 than those with GGT<20 (48.69 vs. 43.85 mmHg, p<0.05); similarly, mean values of SBP (131.66 vs. 116.81 mmHg, p=0.0004) and DBP (82.59 vs. 73.52 mmHg, p=0.0008) are higher in the group with GGT>20. We observed an ascending trend of the mean value of GGT in the different groups of PP; therefore, mean value of GGT was 19.21, 22.65, 23.18 in the PP<40, PP=40-60, respectively PP>60 groups. However, the correlation between PP and GGT was not significant, both in univariate analysis (r=0.14, p=NS) and after adjusting for SBP, DBP, BMI (r=0.12, p=NS). When we analyzed subgroups, the relationship between GGT and PP was more evident in women and in subjects with increased values of BMI.
GGT values are significantly correlated with SBP and DBP, but not with PP, in middle-aged, apparently healthy subjects; even though the highest values of GGT are associated with an increased PP value, further studies would be necessary in order to explain this link.
脉压（PP）值较高——收缩压（SBP）与舒张压（DBP）之差——与心血管风险增加相关；SBP和DBP值与γ-谷氨酰转移酶（GGT）的血清水平相关，在饮酒者和非饮酒者中均如此。此外，一些研究表明，血清GGT水平升高可能与心血管风险增加有关。然而，很少有研究分析GGT与PP之间的关系。在72名受试者（18名男性；54名女性）中，这些受试者为中年人（平均年龄：36.63岁；范围：24 - 54岁），表面健康，我们进行了以下测量：体重、身高（由此计算体重指数[BMI]）、SBP、DBP、PP、标准生化检查，包括GGT（单位/升）。
PP值与SBP相关（r = 0.74，p < 0.001），但与DBP无关（r = 0.15，p =无显著性差异）。GGT与SBP（r = 0.28，p = 0.01）、DBP（r = 0.29，p = 0.01）和BMI（r = 0.41，p < 0.001）显著相关。GGT>20的受试者的PP平均值显著高于GGT<20的受试者（48.69对43.85 mmHg，p < 0.05）；同样，GGT>20组的SBP（131.66对116.81 mmHg，p = 0.0004）和DBP（82.59对73.52 mmHg，p = 0.0008）平均值更高。我们观察到不同PP组中GGT平均值呈上升趋势；因此，PP<40、PP = 40 - 60、PP>60组的GGT平均值分别为19.21、22.65、23.18。然而，在单因素分析中（r = 0.14，p =无显著性差异）以及在调整SBP、DBP、BMI后（r = 0.12，p =无显著性差异），PP与GGT之间的相关性均不显著。当我们分析亚组时，GGT与PP之间的关系在女性和BMI值升高的受试者中更为明显。
在中年表面健康的受试者中，GGT值与SBP和DBP显著相关，但与PP无关；尽管GGT的最高值与PP值升高相关，但为了解释这种联系还需要进一步研究。
