Kotani Kazuhiko, Shimohiro Hisashi, Adachi Seiji, Sakane Naoki
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan.
Tohoku J Exp Med. 2008 Apr;214(4):321-5. doi: 10.1620/tjem.214.321.
Gamma-glutamyl transferase (GGT) is an enzyme present in serum and on most cell surfaces and serves as an oxidative stress marker. Although serum GGT is associated with hypertension development, little data are available on the associations between GGT and hypertension among populations with diabetes mellitus (DM). Our aim was to investigate the potential association between the changes in systolic or diastolic blood pressure (SBP/DBP) and the GGT level in type 2 DM subjects, in comparison with non-DM subjects. In 179 non-DM and 177 DM subjects, SBP/DBP, body mass index (BMI), fasting plasma glucose, serum asparate aminotransferase, alanine aminotransferase and GGT were measured at the baseline and after a 1-year period. Between these 2-measurement points, in non-DM subjects, SBP and DBP levels were significantly increased, while GGT tended to increase. In contrast, in DM subjects, the mean levels of SBP, DBP and GGT remained unchanged. Multivariate analysis revealed that in non-DM subjects the degree of increase in SBP was significantly and positively correlated to that of GGT (beta = 0.165), along with age and BMI. Likewise, the increase in DBP was correlated to that of GGT in non-DM subjects (beta = 0.170). In contrast, in DM subjects, the degree of increase in SBP was significantly correlated to that of only GGT (beta = 0.166). These results suggest that the presence of DM may attenuate the effects of GGT on DBP.
γ-谷氨酰转移酶（GGT）是一种存在于血清和大多数细胞表面的酶，可作为氧化应激标志物。虽然血清GGT与高血压的发生有关，但关于糖尿病（DM）人群中GGT与高血压之间的关联的数据很少。我们的目的是研究2型糖尿病患者与非糖尿病患者相比，收缩压或舒张压（SBP/DBP）变化与GGT水平之间的潜在关联。在179名非糖尿病患者和177名糖尿病患者中，在基线和1年后测量了SBP/DBP、体重指数（BMI）、空腹血糖、血清天冬氨酸转氨酶、丙氨酸转氨酶和GGT。在这两个测量点之间，非糖尿病患者的SBP和DBP水平显著升高，而GGT有升高趋势。相比之下，糖尿病患者的SBP、DBP和GGT平均水平保持不变。多变量分析显示，在非糖尿病患者中，SBP的升高程度与GGT的升高程度显著正相关（β = 0.165），同时与年龄和BMI也相关。同样，非糖尿病患者中DBP的升高与GGT的升高相关（β = 0.170）。相比之下，在糖尿病患者中，SBP的升高程度仅与GGT的升高程度显著相关（β = 0.166）。这些结果表明，DM的存在可能会减弱GGT对DBP的影响。
