用于黏膜给药的单分散壳聚糖纳米颗粒
Monodisperse chitosan nanoparticles for mucosal drug delivery.
作者信息
Zhang Hong, Oh Megan, Allen Christine, Kumacheva Eugenia
机构信息
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
出版信息
Biomacromolecules. 2004 Nov-Dec;5(6):2461-8. doi: 10.1021/bm0496211.
Chitosan nanoparticles (CS NPs) of a controlled size (below 100 nm) and narrow size distribution were obtained through the process of ionic gelation between CS and sodium tripolyphosphate (TPP). A high degree of CS deacetylation and narrow polymer molecular weight distribution were demonstrated to be critical for the controlling particle size distribution. Properties of the CS NPs were examined at different temperatures, values of pH, and ratios of CS to TPP. The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degrees C.
通过壳聚糖（CS）与三聚磷酸钠（TPP）之间的离子凝胶化过程，获得了尺寸可控（低于100 nm）且尺寸分布狭窄的壳聚糖纳米颗粒（CS NPs）。结果表明，高脱乙酰度的CS和狭窄的聚合物分子量分布对于控制颗粒尺寸分布至关重要。在不同温度、pH值以及CS与TPP的比例条件下，对CS NPs的性质进行了研究。将模型蛋白牛血清白蛋白包封到纳米颗粒中，并在37℃的生理相关介质中检测其体外释放曲线。
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