García Luján R, Echave-Sustaeta J M, García Quero C, Pérez González V, Villena Garrido V, López Encuentra A
Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Arch Bronconeumol. 2004 Nov;40(11):537-9.
Lymphoid interstitial pneumonia (LIP) is a rare entity characterized by the infiltration of interstitial tissues and alveolar spaces by lymphocytes, plasma cells, and other lymphoreticular structures. The etiology of LIP is unknown, although associations with autoimmune and infectious factors have been described. The incidence of LIP has risen in recent years, mainly in children with acquired immunodeficiency syndrome (AIDS), while remaining less common in the adult population. No agreement has been reached regarding the diagnostic tests necessary for a firm diagnosis although suspicion is usually based on clinical and radiographic findings, with confirmation provided by examination of histological samples. The most common treatment is corticosteroids, either alone or in combination with other immunosuppressant agents although no evidence from controlled trials is available and cases have been reported in which LIP resolved in AIDS patients with antiretroviral therapy alone. We report the case of a human immunodeficiency virus-infected adult who was diagnosed with LIP by open lung biopsy and who responded to antiretroviral drugs with no need for associated corticosteroid therapy.
淋巴细胞间质性肺炎（LIP）是一种罕见疾病，其特征为淋巴细胞、浆细胞及其他淋巴网状结构浸润间质组织和肺泡腔。尽管已有LIP与自身免疫和感染因素相关的描述，但其病因仍不明。近年来LIP的发病率有所上升，主要见于获得性免疫缺陷综合征（AIDS）患儿，而在成人中仍较少见。对于确诊所需的诊断检查尚未达成共识，尽管怀疑通常基于临床和影像学表现，并通过组织学样本检查加以证实。最常用的治疗方法是单独使用皮质类固醇或与其他免疫抑制剂联合使用，尽管尚无对照试验的证据，且有报道称仅接受抗逆转录病毒治疗的AIDS患者的LIP病情得到缓解。我们报告了一例通过开胸肺活检诊断为LIP的成人人类免疫缺陷病毒感染者，该患者对抗逆转录病毒药物有反应，无需联合皮质类固醇治疗。
