Gollasch Maik, Dubrovska Galyna
LSU Health Sciences Center, Physiology, 1901 Perdido Street, Box P7-3, New Orleans, LA 70112-1393, USA.
Trends Pharmacol Sci. 2004 Dec;25(12):647-53. doi: 10.1016/j.tips.2004.10.005.
Recent studies propose a paracrine role for periadventitial adipose tissue in the regulation of vascular tone. This regulation depends on the anatomical integrity of the periadventitial adipose tissue and involves adipocyte-derived relaxing factor (ADRF). Although the nature of ADRF is largely unknown, it is released by periadventitial adipocytes and induces vasorelaxation by opening K+ channels in the plasma membrane of smooth muscle cells. Alterations in the paracrine role of periadventitial adipose tissue might have a role in vascular dysfunction in hypertension and metabolic disease. Therefore, understanding alterations in ADRF release and the K+ channels involved will help further our understanding of the increased cardiovascular risk and development of chronic vascular disease in obesity. Furthermore, ADRF and perhaps its putative targets might represent exciting new targets for the development of drugs to treat cardiovascular disorders.
最近的研究提出，血管外膜脂肪组织在血管张力调节中具有旁分泌作用。这种调节依赖于血管外膜脂肪组织的解剖完整性，并涉及脂肪细胞衍生的舒张因子（ADRF）。尽管ADRF的本质在很大程度上尚不清楚，但它由血管外膜脂肪细胞释放，并通过打开平滑肌细胞质膜中的钾通道诱导血管舒张。血管外膜脂肪组织旁分泌作用的改变可能在高血压和代谢性疾病的血管功能障碍中起作用。因此，了解ADRF释放的改变以及所涉及的钾通道将有助于我们进一步理解肥胖中增加的心血管风险和慢性血管疾病的发展。此外，ADRF及其可能的靶点可能代表了开发治疗心血管疾病药物的令人兴奋的新靶点。
