Zent Olaf, Plentz Annelie, Schwarz Tino F, Frühwein Nikolaus, Kuhr Hans B, Broeker Michael, Banzhoff Angelika, Jilg Wolfgang
Chiron Vaccines, Marburg, Germany.
Vaccine. 2004 Dec 2;23(3):312-5. doi: 10.1016/j.vaccine.2004.06.007.
In order to evaluate the need for further booster immunizations, 222 subjects aged 20-52 years, who had received the first booster dose with a new tick-borne encephalitis (TBE) vaccine in a preceding study, were invited for a serological follow-up. A total of 191 and 182 adult subjects were analyzed for the persistence of neutralizing TBE antibodies at 1 and 2 years following the first booster immunization, respectively. Both serological follow-ups revealed high levels of neutralizing TBE antibodies in more than 99% of subjects. Although an expected decline of the respective geometric mean titers (GMTs) was noted after booster immunization, the titers were still far above the values noted after primary immunization at the 2-year follow-up. The kinetic curve clearly indicates a longer persistence of neutralizing TBE antibodies than currently expected. To conclude, these results suggest that the administration of a further booster dose 3 years after the first one (according to current recommendations) does not seem to be necessary in this study population.
为了评估进一步加强免疫的必要性，邀请了222名年龄在20至52岁之间的受试者进行血清学随访，这些受试者在之前的一项研究中接受了新型蜱传脑炎（TBE）疫苗的首次加强剂量。分别对191名和182名成年受试者在首次加强免疫后1年和2年时的TBE中和抗体持久性进行了分析。两次血清学随访均显示，超过99%的受试者中TBE中和抗体水平较高。尽管加强免疫后各自的几何平均滴度（GMT）出现了预期的下降，但在2年随访时，这些滴度仍远高于初次免疫后的水平。动力学曲线清楚地表明，TBE中和抗体的持久性比目前预期的更长。总之，这些结果表明，在本研究人群中，在首次加强免疫3年后（按照目前的建议）再接种一剂加强疫苗似乎没有必要。
