不同形式巨噬细胞活化与极化中的趋化因子系统
The chemokine system in diverse forms of macrophage activation and polarization.
作者信息
Mantovani Alberto, Sica Antonio, Sozzani Silvano, Allavena Paola, Vecchi Annunciata, Locati Massimo
机构信息
Centro di Eccellenza per l'Innovazione Diagnostica e Terapeutica (IDET), Institute of General Pathology, University of Milan, I-20133 Milan, Italy; Istituto di Ricerche Farmacologiche Mario Negri, I-20157 Milan, Italy.
出版信息
Trends Immunol. 2004 Dec;25(12):677-86. doi: 10.1016/j.it.2004.09.015.
Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
可塑性和功能极化是单核吞噬细胞系统的标志。在此，我们综述不同形式的巨噬细胞激活和极化（M1、M2a、M2b、M2c）的新关键特性，这些代表了一个连续统一体的两端。特别是，最近的证据表明趋化因子系统的差异调节将极化的巨噬细胞整合到抵抗或促进微生物病原体和肿瘤的途径中，或免疫调节、组织修复和重塑途径中。
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