Mantovani Alberto, Sozzani Silvano, Locati Massimo, Allavena Paola, Sica Antonio
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milan, Italy.
Trends Immunol. 2002 Nov;23(11):549-55. doi: 10.1016/s1471-4906(02)02302-5.
Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
单核吞噬细胞是多功能细胞，可根据微环境信号表达不同的功能程序。完全极化的M1和M2（或替代性活化）巨噬细胞是连续功能状态的两个极端。浸润肿瘤组织的巨噬细胞受肿瘤来源和T细胞来源的细胞因子驱动，获得极化的M2表型。这些功能极化的细胞，以及肿瘤中存在的取向相似或未成熟的树突状细胞，在颠覆适应性免疫以及促进肿瘤生长和进展的炎症回路中起关键作用。
