Pinto Luciano Ribeiro, Seabra Maria de Lourdes, Tufik Sergio
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
Sleep. 2004 Sep 15;27(6):1089-92. doi: 10.1093/sleep/27.6.1089.
Since there is no consensus definition of sleep onset, we studied different aspects of initial sleep periods in healthy volunteers taking melatonin. Two criteria for sleep latency were used: 10 minutes of uninterrupted sleep and 1.5 minutes of stage 1 sleep.
Forty healthy male volunteers (mean age 28 +/- 5 years) were assigned to 2 groups: 30 ingested melatonin and 10 placebo.
All volunteers underwent an initial polysomnogram (baseline) after a 1-night adaptation period. The next day, the placebo or a 10-mg dose of melatonin was administered for 28 days, 1 hour before sleep time, in double-blind fashion. The second polysomnogram was recorded on day 14.
Sleep laboratory
Chronic melatonin administration led to a significant reduction in sleep latency, using only the criterion 10 minutes of uninterrupted sleep. This effect suggests that melatonin may have a hypnotic effect, and the use of melatonin may lead to better sleep consolidation.
These results show differences that have clinical implications, since the criteria used to diagnose initial insomnia were based on sleep onset.
由于睡眠起始尚无共识定义，我们研究了服用褪黑素的健康志愿者初始睡眠阶段的不同方面。使用了两种睡眠潜伏期标准：连续10分钟不间断睡眠和1.5分钟1期睡眠。
40名健康男性志愿者（平均年龄28±5岁）被分为两组：30人服用褪黑素，10人服用安慰剂。
所有志愿者在经过1晚适应期后进行了首次多导睡眠图检查（基线检查）。第二天，以双盲方式在睡眠时间前1小时给予安慰剂或10毫克剂量的褪黑素，持续28天。在第14天记录第二次多导睡眠图。
睡眠实验室
仅使用连续10分钟不间断睡眠这一标准时，长期服用褪黑素导致睡眠潜伏期显著缩短。这一效应表明褪黑素可能具有催眠作用，且使用褪黑素可能会导致更好的睡眠巩固。
这些结果显示出具有临床意义的差异，因为用于诊断初始失眠的标准是基于睡眠起始的。
