Tzischinsky O, Lavie P
Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Sleep. 1994 Oct;17(7):638-45. doi: 10.1093/sleep/17.7.638.
The present study investigated the hypnotic effects of 5 mg melatonin in comparison with placebo when administered at 1200, 1700, 1900 and 2100 hours. Eighteen young adults were studied with the 7/13 ultrashort sleep-wake paradigm after an overnight sleep deprivation. Melatonin was administered according to a double-blind Latin square design. After each administration, melatonin significantly increased sleep propensity, the spectral power in the theta, delta and spindles bands, and subjective sleepiness. It significantly decreased the power in the alpha and beta bands and oral temperature. The latency to maximum effect varied linearly from 3 hours 40 minutes at 1200 hours to 1 hour at 2100 hours. These findings indicate that melatonin possesses a time-dependent hypnotic effect and suggest that endogenous melatonin may participate in sleep-wake regulation.
本研究调查了在1200、1700、1900和2100时给予5毫克褪黑素与安慰剂相比的催眠效果。18名年轻成年人在经过一夜睡眠剥夺后，采用7/13超短睡眠-清醒模式进行研究。褪黑素按照双盲拉丁方设计给药。每次给药后，褪黑素显著增加睡眠倾向、θ波、δ波和纺锤波频段的频谱功率以及主观嗜睡感。它显著降低α波和β波频段的功率以及口腔温度。达到最大效应的潜伏期从1200时的3小时40分钟到2100时的1小时呈线性变化。这些发现表明褪黑素具有时间依赖性催眠作用，并提示内源性褪黑素可能参与睡眠-觉醒调节。
