Karkos P D, Assimakopoulos D, Issing W J
Department of Otolaryngology, The Freeman Hospital, Newcastle Upon Tyne, UK.
Int J Pediatr Otorhinolaryngol. 2004 Dec;68(12):1489-92. doi: 10.1016/j.ijporl.2004.07.019.
The pathogenesis of middle ear infections in children is multifactorial and includes infection, anatomical factors, impaired immunologic status, allergy, familial predisposition, male sex, method of feeding and environmental factors. Glue ear remains the commonest cause of deafness in childhood. Gastroesophageal reflux (GOR) is a common problem in the newborn and preschool periods. Recent research suggests that it may be related to eustachian tube dysfunction and otitis media.
We review the literature and discuss the possible relationship between Gastroesophageal reflux and otitis media in children.
The current data are not enough to support antireflux treatment in children with refractory middle ear infections. More prospective randomised placebo-controlled studies are needed.
儿童中耳感染的发病机制是多因素的，包括感染、解剖因素、免疫状态受损、过敏、家族易感性、男性性别、喂养方式和环境因素。胶耳仍然是儿童期耳聋的最常见原因。胃食管反流（GOR）在新生儿期和学龄前是一个常见问题。最近的研究表明，它可能与咽鼓管功能障碍和中耳炎有关。
我们回顾文献并讨论胃食管反流与儿童中耳炎之间的可能关系。
目前的数据不足以支持对难治性中耳感染儿童进行抗反流治疗。需要更多前瞻性随机安慰剂对照研究。
