Okumura Akihisa, Tanabe Takuya, Kato Toru, Hayakawa Fumio, Watanabe Kazuyoshi
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Brain Dev. 2004 Dec;26(8):525-9. doi: 10.1016/j.braindev.2004.02.009.
The aim of this study was to clarify the efficacy and safety of lidocaine tape therapy (LDT) in patients with convulsions with mild gastroenteritis (CwG). Twenty-one consecutive episodes of CwG were treated with LDT therapy. The dose of LDT was 36 mg in patients with body weights of <15 kg, 54 mg in those with body weights between 15 and 20 kg, and 72 mg in those with body weights of >20 kg. LDT was attached on the back of each patient every 12 h. Application of LDT was continued for 48 h. The serum levels of lidocaine (LD) were measured 4 h after the first attachment of LDT. The seizures completely ceased in 13 episodes (62%) after the application of LDT, while a recurrence of seizures was observed in the other 8 episodes. Drip infusion of LD was performed in 4 of these 8 episodes. The serum LD levels were only measurable in 6 infants (average, 0.4 microg/ml; range, 0.2-0.5 microg/ml). In the other patients, the serum LD levels were below the lower limit of measurement. Adverse effects of LDT were not observed in any patients. LDT therapy was safe and effective in patients with CwG.
本研究的目的是阐明利多卡因贴剂疗法（LDT）对轻度肠胃炎惊厥（CwG）患者的疗效和安全性。连续21例CwG发作患者接受了LDT治疗。体重<15 kg的患者LDT剂量为36 mg，体重在15至20 kg之间的患者为54 mg，体重>20 kg的患者为72 mg。每12小时在每位患者背部贴上LDT。LDT持续应用48小时。在首次贴上LDT后4小时测量利多卡因（LD）的血清水平。应用LDT后，13例发作（62%）的惊厥完全停止，而其他8例出现惊厥复发。这8例中的4例进行了LD静脉滴注。仅在6例婴儿中可测量到血清LD水平（平均0.4μg/ml；范围0.2 - 0.5μg/ml）。在其他患者中，血清LD水平低于测量下限。未在任何患者中观察到LDT的不良反应。LDT疗法对CwG患者安全有效。
