Okumura Akihisa, Uemura Naoko, Negoro Tamiko, Watanabe Kazuyoshi
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Brain Dev. 2004 Apr;26(3):164-7. doi: 10.1016/S0387-7604(03)00121-9.
The aim of this study was to clarify the efficacy of antiepileptic drugs during a cluster of seizures in patients with convulsions with mild gastroenteritis (CwG). We retrospectively investigated the details of antiepileptic treatment in 110 consecutive episodes in 103 patients with CwG. The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode. Drugs were judged as effective when seizure cessation was achieved after administration of the drug. As the first drug, diazepam (DZP)/bromazepam (BZP) was effective in 38%, phenobarbital (PB) in 40%, and lidocaine (LD) in 100%. As the second drug, DZP/BZP was effective in 42%, PB in 69%, and LD in 100%. As the third drug, PB was effective in 70%. When the efficacy of the first doses of PB and LD were compared, the efficacy rate was significantly higher for LD than for PB (P = 0.047). In conclusion, LD was effective for the cessation of seizures in patients with CwG.
本研究的目的是阐明抗癫痫药物对轻度肠胃炎惊厥患者（CwG）发作丛集期的疗效。我们回顾性调查了103例CwG患者连续110次发作的抗癫痫治疗细节。在每次发作中研究了癫痫发作的时间进程和抗癫痫药物的使用情况。当给药后癫痫发作停止时，判断药物有效。作为首选用药，地西泮（DZP）/溴西泮（BZP）有效率为38%，苯巴比妥（PB）为40%，利多卡因（LD）为100%。作为次选用药，DZP/BZP有效率为42%，PB为69%，LD为100%。作为第三选用药，PB有效率为70%。比较PB和LD首剂的疗效时，LD的有效率显著高于PB（P = 0.047）。总之，LD对CwG患者的癫痫发作停止有效。
