采用高效液相色谱法测定唑吡坦合成过程并进行过程控制。
Determination and in-process control of zolpidem synthesis by high-performance liquid chromatography.
作者信息
Laviana L, Mangas C, Fernández-Marí F, Bayod M, Blanco D
机构信息
Department of Physical and Analytical Chemistry, University of Oviedo, Química Física y Analítica, Julian Clavería, Oviedo, Spain.
出版信息
J Pharm Biomed Anal. 2004 Nov 19;36(4):925-8. doi: 10.1016/j.jpba.2004.08.025.
A high-performance liquid chromatographic assay with diode-array detection has been developed for the in-process control of zolpidem synthesis and for the analysis of the drug and its synthetic intermediates. The separation uses a 4.6mm i.d. reversed-phase Kromasil C(18) (150 mm) column, 5 microm particle size with a gradient elution mode of acetonitrile and 0.02 M NH(4)OAc (adjusted to pH 8.0) as the mobile phase (flow rate 1.0 mlmin(-1)). The analysis is performed in 12 min. The method is simple, rapid and highly specific.
已开发出一种带二极管阵列检测的高效液相色谱法，用于唑吡坦合成的过程控制以及该药物及其合成中间体的分析。分离使用内径4.6mm的反相Kromasil C(18)（150mm）色谱柱，粒径5微米，以乙腈和0.02M NH(4)OAc（调至pH 8.0）作为流动相的梯度洗脱模式（流速1.0 mlmin(-1)）。分析在12分钟内完成。该方法简单、快速且具有高度特异性。
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