Yuan Jian-Min, Ross Ronald K, Gao Yu-Tang, Qu Yong-Hua, Chu Xin-Di, Yu Mimi C
Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, MC 9175, 1441 Eastlake Avenue, Los Angeles, CA 90033-0800, USA.
Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1772-80.
Data on blood levels of specific carotenoids and vitamins in relation to gastric cancer are scarce. Little is known about the relationship between prediagnostic serum levels of carotenoids other than beta-carotene and risk of gastric cancer especially in non-Western populations. Prediagnostic serum concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and vitamin C were determined on 191 cases and 570 matched controls within a cohort of 18,244 middle-aged or older men in Shanghai, China, with a follow-up of 12 years. High serum levels of alpha-carotene, beta-carotene, and lycopene were significantly associated with reduced risk of developing gastric cancer (all Ps for trend </= 0.05); the odds ratios (95% confidence intervals) for the highest versus the lowest quartile of alpha-carotene, beta-carotene, and lycopene were 0.38 (0.13-1.11), 0.54 (0.32-0.89), and 0.55 (0.30-1.00), respectively. Increased serum level of vitamin C was significantly associated with reduced risk of gastric cancer among men who neither smoked cigarettes over lifetime nor consumed >/=3 drinks of alcohol per day; the odds ratios (95% confidence intervals) for the second, third, and fourth quartile categories were 0.69 (0.28-1.70), 0.36 (0.14-0.94), and 0.39 (0.15-0.98), respectively, compared with the lowest quartile of vitamin C (P for trend = 0.02). There were no statistically significant relationships of serum levels of beta-cryptoxanthin, lutein/zeaxanthin, retinol, alpha-tocopherol, and gamma-tocopherol with gastric cancer risk. The present study implicates that dietary carotenes, lycopene, and vitamin C are potential chemopreventive agents for gastric cancer in humans.
关于特定类胡萝卜素和维生素的血液水平与胃癌关系的数据很少。对于除β-胡萝卜素之外的其他类胡萝卜素的诊断前血清水平与胃癌风险之间的关系知之甚少，尤其是在非西方人群中。在中国上海18244名中年或老年男性队列中，对191例病例和570名匹配对照测定了诊断前血清中α-胡萝卜素、β-胡萝卜素、β-隐黄质、番茄红素、叶黄素/玉米黄质、视黄醇、α-生育酚、γ-生育酚和维生素C的浓度，并进行了12年的随访。血清中α-胡萝卜素、β-胡萝卜素和番茄红素水平高与患胃癌风险降低显著相关（所有趋势P值≤0.05）；α-胡萝卜素、β-胡萝卜素和番茄红素最高四分位数与最低四分位数相比的比值比（95%置信区间）分别为0.38（0.13至1.11）、0.54（0.32至0.89）和0.55（0.30至1.00）。血清维生素C水平升高与一生中既不吸烟也不每天饮用≥3杯酒精饮料的男性患胃癌风险降低显著相关；与维生素C最低四分位数相比，第二、第三和第四四分位数类别的比值比（95%置信区间）分别为0.69（0.28至1.70）、0.36（0.14至0.94）和0.39（0.15至0.98）（趋势P值 = 0.02）。血清β-隐黄质、叶黄素/玉米黄质、视黄醇、α-生育酚和γ-生育酚水平与胃癌风险无统计学显著关系。本研究表明，膳食中的胡萝卜素、番茄红素和维生素C是人类胃癌潜在的化学预防剂。
