Suzuki Koji, Ito Yoshinori, Wakai Kenji, Kawado Miyuki, Hashimoto Shuji, Toyoshima Hideaki, Kojima Masayo, Tokudome Shinkan, Hayakawa Norihiko, Watanabe Yoshiyuki, Tamakoshi Koji, Suzuki Sadao, Ozasa Kotaro, Tamakoshi Akiko
Department of Public Health, Fujita Health University School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1781-7.
Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P(trend) = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P(trend) = 0.140). Further adjustment for serum total cholesterol and alpha-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P(trend) = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.
氧化应激在致癌过程中起着重要作用，但很少有流行病学研究探讨其与结直肠癌风险的关联。在日本癌症风险评估协作队列研究中的一项病例对照研究中，调查了血清氧化型低密度脂蛋白（oxLDL）和oxLDL抗体（oLAB）水平与结直肠癌风险之间的关系。1988年至1990年间，从39242名男性和女性中收集了基线血清样本和生活方式信息。其中，到1999年共确定了161例结直肠癌事件和死亡病例，并为395名对照者匹配了性别、年龄和研究区域。对119例病例和316名对照者测量了血清oxLDL水平，对153例病例和376名对照者测量了血清oLAB水平。经混杂因素调整后，oxLDL四分位数的比值比（95%置信区间）分别为1.55（0.70 - 3.46）、1.90（0.84 - 4.28）和3.65（1.50 - 8.92）（P趋势 = 0.004），oLAB的比值比分别为0.98（0.54 - 1.80）、0.75（0.39 - 1.48）和1.68（0.90 - 3.13）（P趋势 = 0.140）。进一步调整血清总胆固醇和α-生育酚后，这些关联没有实质性变化。血清oxLDL最高四分位数与最低四分位数的比值比（95%置信区间）为3.40（1.09 - 10.58；P趋势 = 0.045）。仅对结肠癌病例及其相应对照进行分析，血清oxLDL和oLAB水平与风险之间也呈现出相似的关系。总之，血清oxLDL水平升高可能会增加结直肠癌风险。
