Li Juan, Morcom Alexa M, Rugg Michael D
Chinese Academy of Sciences, Beijing, China.
Cogn Affect Behav Neurosci. 2004 Sep;4(3):279-93. doi: 10.3758/cabn.4.3.279.
The neural correlates of successful episodic retrieval (recollection), as reflected in event-related potentials (ERPs), were investigated in young (ca 20 years; n = 18) and older (ca 70 years; n = 16) healthy individuals. Subjects classified a series of pictures according to whether each item was new or had been encountered at study in the context of an animacy or a size judgment task. By manipulating the number of times items were presented for study, subsets of test items were formed for which source accuracy did not differ according to age. Relative to ERPs elicited by unstudied pictures, ERPs elicited by items attracting equivalent levels of source accuracy showed marked age-related differences. Those from younger subjects demonstrated the positive-going left parietal and right frontal old/new effects described in several previous studies of source memory. By contrast, analogous ERPs from older subjects contained a large left-lateralized negative effect that overshadowed the positive-going effects evident in the young. No age-related differences in either parietal or frontal ERP old/new effects were detected at electrode sites overlying the right hemisphere. It is possible that the age-related ERP differences observed in this task primarily reflect the use of different kinds of information as a basis for source judgments.
通过事件相关电位（ERP）反映的成功情景记忆提取（回忆）的神经关联，在年轻（约20岁；n = 18）和年长（约70岁；n = 16）的健康个体中进行了研究。受试者根据每个项目是新的还是在有生命或大小判断任务的学习中遇到过，对一系列图片进行分类。通过操纵项目呈现以供学习的次数，形成了测试项目的子集，其来源准确性在年龄上没有差异。相对于未学习图片引发的ERP，由吸引同等水平来源准确性的项目引发的ERP显示出明显的年龄相关差异。年轻受试者的ERP表现出先前几项来源记忆研究中描述的正向左侧顶叶和右侧额叶新旧效应。相比之下，年长受试者的类似ERP包含一个大的左侧化负效应，掩盖了年轻人中明显的正向效应。在右半球上方的电极部位，未检测到顶叶或额叶ERP新旧效应的年龄相关差异。在这项任务中观察到的与年龄相关的ERP差异可能主要反映了使用不同类型的信息作为来源判断的基础。
