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墨西哥南部三种实验室品系白纹按蚊(双翅目:蚊科)对当地间日疟原虫环子孢子蛋白表型的易感性。

Susceptibility of three laboratory strains of Anopheles albimanus (Diptera: Culicidae) to coindigenous Plasmodium vivax circumsporozoite protein phenotypes in southern Mexico.

作者信息

Gonzalez-Ceron L, Rodriguez M H, Santillan F V, Hernandez J E, Wirtz R A

机构信息

Centro de Investigación de Paludismo, Instituto Nacional de Salud Pública, P.O. Box 537, Tapachula, Chiapas, 30700 Mexico.

出版信息

J Med Entomol. 2000 May;37(3):331-4.

PMID:15535573
Abstract

The susceptibility to two coindigenous Plasmodium vivax Grassi & Feletti phenotypes VK210 and VK247 of three colonized Anopheles albimanus Wiedemann strains (white-striped, green and brown) from southern Mexico was investigated. Mosquitoes of the three strains were simultaneously fed with P. vivax-infected patient blood and examined 1 wk later for the presence of oocysts. The circumsporozoite protein phenotype type (VK210 and VK247) was determined by immunoflorescence of salivary gland sporozoites using monoclonal antibodies. The proportions of specimens infected and the number of oocyst per mosquito indicated that all mosquito strains were more susceptible to the phenotype VK210 than to VK247, but the white-striped strain was more susceptible to both parasite phenotypes than the other two strains.

摘要

研究了来自墨西哥南部的三种定殖白纹伊蚊(Wiedemann)品系(白纹、绿色和棕色)对两种本地间日疟原虫(Grassi & Feletti)表型VK210和VK247的易感性。这三种品系的蚊子同时吸食感染间日疟原虫的患者血液,并在1周后检查是否存在卵囊。使用单克隆抗体通过唾液腺子孢子的免疫荧光确定环子孢子蛋白表型类型(VK210和VK247)。感染标本的比例和每只蚊子的卵囊数量表明,所有蚊子品系对VK210表型的易感性均高于VK247,但白纹品系对两种寄生虫表型的易感性均高于其他两个品系。

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引用本文的文献

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Ookinete destruction within the mosquito midgut lumen explains Anopheles albimanus refractoriness to Plasmodium falciparum (3D7A) oocyst infection.在蚊子中肠腔中破坏卵囊可解释按蚊属对恶性疟原虫(3D7A)卵囊感染的抗性。
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