Ramia Jose Manuel, Mansilla Alfonso, Villar Jesús, Muffak Karim, Garrote Daniel, Ferron Jose Antonio
Hepatobiliary and Liver Transplantation Unit, Department of Surgery, Hospital Virgen de las Nieves, Granada, Spain.
JOP. 2004 Nov 10;5(6):495-7.
Most tumors affecting Vater's Ampulla are adenocarcinomas and other histological variants are less frequent. A review of the literature revealed only seven previously reported cases of signet ring cell carcinoma of the ampulla of Vater. The presence of this kind of tumor has no clear histological explanation. Two possible theories have been proposed: the presence of gastric heterotopia in the ampulla of Vater or the existence of a perivaterian duodenal heterotopia of ulcerous etiology as the origin of a signet ring cell tumor which secondarily invades the ampulla of Vater.
We performed a pancreatoduodenectomy in a 67-year-old woman with a T2N0M0 ampulla tumor. A histologic study revealed a signet ring cell neoplasm.
Etiology and survival of signet ring cell carcinoma of Vater's ampulla is not well-defined in the literature due to the extreme rarity of this disease. Duodenopancreatectomy with pylorus preservation is the treatment of choice.
大多数影响壶腹的肿瘤为腺癌，其他组织学类型则较为少见。文献回顾显示，此前仅报道过7例壶腹印戒细胞癌病例。这种肿瘤的存在尚无明确的组织学解释。已提出两种可能的理论：壶腹中存在胃异位组织，或存在源于溃疡病因的壶腹周围十二指肠异位组织，作为印戒细胞瘤的起源，继而侵犯壶腹。
我们为一名67岁患有T2N0M0壶腹肿瘤的女性实施了胰十二指肠切除术。组织学研究显示为印戒细胞肿瘤。
由于本病极为罕见，壶腹印戒细胞癌的病因及生存率在文献中尚无明确界定。保留幽门的十二指肠胰切除术是首选治疗方法。
