Singh Sonal, Nautiyal Amit, Dolan James G
Department of Internal Medicine, Unity Health System, Rochester, NY 14626, USA.
JOP. 2004 Nov 10;5(6):502-4.
Few data exist about the incidence of drug-induced pancreatitis in the general population. Drugs are related to the etiology of pancreatitis in about 1.4-2% of cases. While statins are generally well tolerated they have been known to be associated with pancreatitis. Acute pancreatitis has been reported in a few cases treated with atorvastatin, fluvastatin, lovastatin, simvastatin and pravastatin.
We report the case of a 77-year-old patient who developed acute pancreatitis after treatment with rosuvastatin, which resolved on withdrawal of the medication. She had a similar episode of pancreatitis a year ago precipitated by atorvastatin, which resolved on withdrawal. Extensive workup on both occasions failed to reveal any other etiology for the pancreatitis.
To our knowledge this is the first report of rosuvastatin-induced pancreatitis. The occurrence of pancreatitis with two different statins in our patient argues that statins induced pancreatitis may be a class-effect of statins. With statin prescriptions on the rise clinicians need to be aware of this complication of statin treatment and remember that the newest statin, rosuvastatin is not dissimilar to the other statins in causing pancreatitis.
关于普通人群中药物性胰腺炎的发病率，现有数据较少。在约1.4%-2%的胰腺炎病例中，药物与病因有关。虽然他汀类药物一般耐受性良好，但已知其与胰腺炎有关。已有少数接受阿托伐他汀、氟伐他汀、洛伐他汀、辛伐他汀和普伐他汀治疗的病例报告发生急性胰腺炎。
我们报告一例77岁患者，在接受瑞舒伐他汀治疗后发生急性胰腺炎，停药后病情缓解。一年前，她曾因阿托伐他汀引发过类似的胰腺炎发作，停药后病情缓解。两次全面检查均未发现胰腺炎的任何其他病因。
据我们所知，这是瑞舒伐他汀所致胰腺炎的首例报告。我们的患者使用两种不同他汀类药物均发生胰腺炎，这表明他汀类药物所致胰腺炎可能是该类药物的共同作用。随着他汀类药物处方量的增加，临床医生需要意识到他汀类药物治疗的这一并发症，并记住最新的他汀类药物瑞舒伐他汀在引发胰腺炎方面与其他他汀类药物并无不同。
